J Korean Neurol Assoc.
2006 Aug;24(4):389-391.
A Case of Glycyrrhizin (Licorice)-induced Hypokalemic Myopathy
- Affiliations
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- 1Department of Neurology, Seoul National University College of Medicine, Seoul, Korea. pks1126@chol.com
- 2Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
Abstract
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Glycyrrhizin, the main ingredient of licorice, may evoke severe hypokalemia and muscle paralysis by its mineralocorticoid effects. We present a 78-year-old man who developed subacute flaccid quadriparesis with a high creatine kinase (CK) level, hypokalemia, metabolic alkalosis, and low plasma renin activity after ingesting licorice daily for two years. A muscle biopsy revealed vacuolar degeneration of myofibers. This case suggests that glycyrrhizin (licorice)-induced hypokalemic myopathy must be included in the differential diagnosis of a patient with generalized muscle weakness and hypokalemia.