J Korean Neurol Assoc.
2003 Apr;21(2):210-212.
Neuromyeloencephalopathy Induced by Inadvertent Intrathecal Vincristine Injection
- Affiliations
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- 1Department of Neurology, College of Medicine, Konyang University, 685 Gasuwon-dong, Seo-gu, Daejeon, 302-718, Korea. drdonsoo@kyuh.co.kr
- 2Department of Pediatrics, College of Medicine, Eulji University, Korea.
Abstract
- Accidental intrathecal vincristine instillation is extremely toxic to the central nervous system. If given intrathecally, it produces a rapidly ascending, usually fatal, neuromyeloencephalopathy. This is a case where a 10-year-old girl received an inadvertent intrathecal administration of vincristine. The clinical course was rapidly progressive and resulted in comatose and vegetative state. Magnetic resornance image at post-injection 11 day showed high signal intensity lesion in cerebellar hemisphere and vermis adjacent to CSF passage third and fourth ventricle on T2 weighted images.
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