J Korean Neurol Assoc.  1994 Sep;12(3):474-483.

Pathogenetic Correlations of Anti-Ganglioside Antibody in Guillain-Barre Sydrome

• Lee GH
• Lee SH
• Lee SB
• Lee KW

Abstract

Guillain-Barre syndrome (GBS) is characterized by similar clinical manifestations which are caused by several factors. But the autoimmune theories seems to be important for understanding its pathomechanism. Recently antibodies to neutral glycolipid, anti-GM1 antibodies, and anti-MAG antibodies have been implicated for possible causative factors in some GBS(Iiyas et al. 1998; Koski et al. 1989; Yu et al. 1990). The author performed the study to understand the pathogenetic correlation of anti-GM1 antibodies whth GBS. The anti-GM1titers were checked by the ELISA method in 30 patients with GBS, 30 other neurological diseases (OND) and 30 normal subjects. All the serafrom GBS patients were taken during the period of acute exacerbation or before 10 to 20 days after the initiation of clinical disability. The positive IgM-type anti-GM1 antibodies were found in 10 out 30 GBS patients (33.3%), and 6 out of 30 OND patients(20%), and none of 30 normal subjects. Clinically, the relative severe course were found in 4 out of 10 (40.0%) antibody-positive and in 4 out of 20 (20.0%) antibody-negative GBS patients,which was not significant statistically. Therefore it is concluded that there could be some correlations of anti-GM1 antibodies with GBS, which needs further investigation.

MeSH Terms

Antibodies
Enzyme-Linked Immunosorbent Assay
Guillain-Barre Syndrome
Humans
Antibodies