J Korean Neuropsychiatr Assoc.
2010 Nov;49(6):653-656.
Two Cases of Reversible Neutropenia Associated with Olanzapine-Valproate Combination Treatment
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- 1Department of Psychiatry, Seoul National Hospital, Seoul, Korea. drshe@hanmail.net
Abstract
- The novel antipsychotic, olanzapine, has structural and pharmacological properties similar to clozaine. Antipsychotic drugs, as well as mood stabilizers, can cause neutropenia, which can progress to life-threatening agranulocytosis if the medication is not discontinued. We report two cases of reversible neutropenia associated with a olanzapine-valproate combination treatment. This report suggests that patients treated with the combination of olanzapine and valproate should be monitored for the occurrence of leukopenia and neutropenia.
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