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Incidence of Neutropenia with Valproate, Antipsychotics, and ADHD Medication Combination Treatment in Children and Adolescents

Oh Y, Joung YS, Choi J

This study's aim was to investigate whether the incidence of neutropenia was higher in subjects who received a combination pharmacotherapy with valproate (VPA), antipsychotics (APs), and attention deficit hyperactivity disorder...
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Histone deacetylase inhibition attenuates hepatic steatosis in rats with experimental Cushing's syndrome

Kim M, Lee HA, Cho HM, Kang SH, Lee E, Kim IK

Cushing's syndrome (CS) is a collection of symptoms caused by prolonged exposure to excess cortisol. Chronically elevated glucocorticoid (GC) levels contribute to hepatic steatosis. We hypothesized that histone deacetylase inhibitors...
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Neosensitization to Multiple Drugs Following Valproate-Induced Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome

Song JM, Jung YE, Park JH, Kim MD, Cheon MS, Lee CI

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome is associated with severe skin eruptions, fever, hematological abnormalities, and multi-organ involvement. Although aromatic anticonvulsant drugs have been frequently associated with...
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Neuroleptic Malignant Syndrome Associated with Valproate in an Adolescent

Yıldırım V, Direk MC, Güneş S, Okuyaz C, Toros F

Neuroleptic malignant syndrome (NMS) is a life-threatening idiosyncratic reaction that usually occurs after the administration of antipsychotic drugs. Antidepressants, benzodiazepines, and antiepileptic drugs are also suggested to be associated with...
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Long-Term Treatment Response to Lithium and Valproate in Patients with Bipolar 1 Disorder Treated More Than 2 Years : A Retrospective Study

Ahn SW, Yang SY, Choi Y, Hong KS

OBJECTIVES: Treatment response of bipolar disorders (BDs) to long-term mood stabilizers maintenance has not been well explored because of complicated clinical and treatment courses. This study aims at investigating long-term...
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Clinical Response to Valproate in Patients with Migraine

Ichikawa M, Katoh H, Kurihara T, Ishii M

BACKGROUND AND PURPOSE: Valproate is used as a prophylactic drug for migraine, but it is not be effective in all patients. We used medical records to investigate which clinical factors...
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Therapeutic Dose Range of Valproate-Induced Hyperammonemic Encephalopathy: A Case Report

Maeng SR, Roh JH, Kim CE

We report a case of a 34-year-old woman who was in temporary delirium and hyperammonemia during treatment of bipolar affective disorder with valproate. Patient showed delirium after 20 days of...
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A Case of Nasu-Hakola Disease without Fractures or Consanguinity Diagnosed Using Exome Sequencing and Treated with Sodium Valproate

Yamazaki K, Yoshino Y, Mori Y, Ochi S, Yoshida T, Ishimaru T, Ueno SI

Nasu-Hakola disease (NHD) is a rare autosomal recessive neuropsychiatric disorder characterized by bone cysts, fractures, and cognitive impairment. Two genes are responsible for the development of NHD; TYROBP and TREM2....
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Valproate-induced Hyperammonemic Encephalopathy: A Case Report

Yoo JY, Yang HS

Valproate is widely used because of broad spectrum of action, but it can produce an encephalopathy resulting from hyperammonemia even at the therapeutic range of valproate and is called as...
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Safety Evaluation of Topical Valproate Application

Choi SY, Seop SY, Hyun MY, Yoo KH, Kim BJ, Kim MN, Cho JW

  • KMID: 2317820
  • Toxicol Res.
  • 2013 Jun;29(2):87-90.
The potential role of topical valproate (VPA) in hair regrowth has been recently suggested. However, safety reports of VPA as a topical formulation are lacking. Therefore, in the present study,...
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Effects of Long-Term Combination Treatment with Valproate and Atypical Antipsychotics on Bone Mineral Density and Bone Metabolism in Premenopausal Patients with Bipolar Disorder: A Preliminary Study

Yang J, Joe SH, Lee MS, Ko YH, Jung IK, Kim SH

  • KMID: 2316093
  • Psychiatry Investig.
  • 2011 Sep;8(3):256-261.
OBJECTIVE: We investigated bone mineral density (BMD) and bone metabolism in female bipolar patients who were undergoing long-term treatment with valproate combined with a low-dose atypical antipsychotic. METHODS: Nineteen premenopausal women...
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Predictive Factors for Valproate Treatment in Childhood Absence Epilepsy

Chi GH, Hwang TG

  • KMID: 2329440
  • J Korean Child Neurol Soc.
  • 2010 May;18(1):7-13.
PURPOSE: To determine the clinical and demographic factors associated with long-term remission of valproate(VPA) therapy in childhood absence epilepsy. METHODS: Fifty-six cases of childhood and juvenile absence epilepsy were identified by...
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Two Cases of Reversible Neutropenia Associated with Olanzapine-Valproate Combination Treatment

Kang SH, Oh JK, Lee JI, Chang AK

  • KMID: 2341834
  • J Korean Neuropsychiatr Assoc.
  • 2010 Nov;49(6):653-656.
The novel antipsychotic, olanzapine, has structural and pharmacological properties similar to clozaine. Antipsychotic drugs, as well as mood stabilizers, can cause neutropenia, which can progress to life-threatening agranulocytosis if the...
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Changes in platelet counts caused by valproate in children with epilepsy

We JH, Kim YM, Nam SO

PURPOSE: In adults, valproate (VPA) has been reported to be associated with thrombocytopenia. However, few studies have investigated this association in children, and the factors affecting platelet counts remain controversial....
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Treatment of Lithium-Pilocarpine Induced Status Epilepticus Rat Models According to EEG Stage

Jeon MY, Shin WC, Kim YI, Kim JM, Seo DW

  • KMID: 2185063
  • J Korean Neurol Assoc.
  • 2008 Aug;26(3):200-208.
BACKGROUND: EEG shows a sequence of progressive changes in status epilepticus (SE). Timely antiepileptic drug treatment is an important factor for the prognosis of SE. Here we investigated the effect...
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Common Gene Expression Pattern in the Rat Brain Induced by Several Mood: Stabilizing Drugs

Bae SO, Kim JM, Ahn YM, Lee KY, Roh JW, Yoon JS, Kim YS

  • KMID: 2287067
  • Korean J Psychopharmacol.
  • 2007 Jul;18(4):211-220.
OBJECTIVE: This study sought to identify candidate genes related to the clinical effects of several mood stabilizers through gene expression profiles using microarrays and real time RT-PCR. METHOD: Rats were treated...
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A Case of Valproate-Induced Hyperammonemic Encephalopathy with Triphasic Waves

Koo YH, Kim WC, Kim HS, Kim OJ

  • KMID: 1816513
  • J Korean Epilepsy Soc.
  • 2006 Jun;10(1):60-63.
Valproate is a widely used antiepileptic drug with rarely occurring serious side effects. However, valproate may induce hyperammonemic encephalopathy. A 85-year-old woman was admitted with stuporous mental status. Brain MRI...
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Cognitive Profiles of Lamotrigine in Epilepsy Patients : A Comparative Study with Valproate

Kang KH, Lee JM, Lee HW, Jung DK, Suh CK, Kwon SH, Park SP

  • KMID: 2008749
  • J Korean Epilepsy Soc.
  • 2006 Dec;10(2):146-152.
PURPOSE: To identify cognitive effects of lamotrigine (LTG) compared with valproate (VPA) in epilepsy patients after 1 year of treatment. METHODS: Cognitive tests and subjective complaints of 22 patients with LTG...
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The Pharmacological Treatment of Pediatric Onset Idiopathic Generalized Epilepsies: The Therapeutic Effects of Topiramate, Lamotrigine, and Valproate

Yum MS, You SJ, Kim DS, Ko TS

  • KMID: 2008747
  • J Korean Epilepsy Soc.
  • 2006 Dec;10(2):133-138.
PURPOSE: The majority of patients with idiopathic generalized epilepsy (IGE) are controlled by an antiepileptic drug when appropriately selected. So far, valproate is regarded as the first-line treatment for IGE....
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Changes in Glucose and Cholesterol Level in Schizophrenic Patients Treated with Atypical Antipsychotics or with Valproate Combination

Han DH, Lee JH, Kim TH, Choi JE, Park DB, Kee BS

  • KMID: 2287290
  • Korean J Psychopharmacol.
  • 2004 Jun;15(2):211-218.
OBJECTIVE: The association of obesity, diabetes mellitus, drug compliance, and body image with use of antipsychotic medication has been documented in many studies. We aimed to assess the effects of...
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