J Korean Neuropsychiatr Assoc.  2005 Sep;44(5):568-575.

Event-Related Potential P3a and P3b using 3-Stimulus Auditory "Oddball" Paradigm in the Patients with Schizophrenia

• Jin YT
• Park EJ
• Nam JM
• Han SI
• Jeon YW

Abstract

OBJECTIVES
Using 3-stimulus auditory "oddball" paradigm reflecting fronto/central and temporo/parietal functions simultaneously, we examined patients with schizophrenia.
METHODS
Fifteen patients with schizophrenia from outpatient clinic and fifteen normal controls from hospital staffs were recruited for the study. To elicit P3a and P3b, 3-stimulus auditory oddball paradigm was employed. The 3-stimulus auditory oddball paradigm was composed of standard tone (1,000 Hz, 75 dB, 80%), target tone (2,000 Hz, 75 dB, 10%) and distracter (White noise, 95 dB, 10%).
RESULTS
P3a and P3b were prominent in fronto/central and temporo/parietal areas, respectively, in both schizophrenics and normal controls. The P300 amplitude in patients with schizophrenia was reduced across P3a and P3b (p<0.01). The P300 latency in patients with schizophrenia was delayed across P3a and P3b (p<0.01).
CONCLUSION
These results were consistent with frontal and temporo-parietal lobe dysfunctions in schizophrenics. The 3-stimulus auditory paradigm could be applied for patients with schizophrenia and useful for further exploration the disorder.

Keyword

P300; P3a; P3b; Schizophrenia; 3-stimulus auditory paradigm

MeSH Terms

Ambulatory Care Facilities
Evoked Potentials*
Humans
Noise
Schizophrenia*