J Korean Neuropsychiatr Assoc.  2005 Jul;44(4):489-496.

Characteristics of Sleep Disturbances Correlated with Clinical Parameters in Hemodialysis Patients with Chronic Renal Failure

• Kim SJ
• Jung HH
• Lee JH

Abstract

OBJECTIVES
Sleep disturbances are very common in hemodialysis (HD) patients with chronic renal failure (CRF). This study aimed to examine the characteristics of sleep disturbances, and to illustrate the relationship of sleep parameters with clinical parameters reflecting metabolic dysfunction in HD patients with CRF.
METHODS
The Epworth Sleepiness Scale (ESS) and Sleep Disorders Questionnaire (SDQ) were administered in 26 HD patients with CRF. For fifteen patients with the risk of sleep disorder, nocturnal polysomnographic study (NPSG) and blood sampling were done.
RESULTS
Among 15 patients, 14 patients (93%) were diagnosed as sleep disorders, sleep breathing disorder or periodic limb movements in sleep. Uric acid (UA) was positively correlated with sleep efficiency (r=0.571), and negatively correlated with waking after sleep onset, the amount of stage 1 sleep, and respiratory disturbance index (r=-0.515, -0.564, -0.646). Interleukin-6 was positively correlated with obstructive apnea index (r=0.661).
CONCLUSION
In our study, the difficulty in maintaining sleep was found in HD patients with CRF. It also showed that increased UA was associated with improved sleep maintenance and decreased breathing disturbance during sleep. This might be related with antioxidant effect of UA in CRF. Further studies on total CRF patients including those without the risk of sleep disorder are necessary.

Keyword

Nocturnal polysomnography (NPSG); Sleep parameter; Clinical parameter; Chronic renal failure

MeSH Terms

Antioxidants
Apnea
Extremities
Humans
Interleukin-6
Kidney Failure, Chronic*
Surveys and Questionnaires
Renal Dialysis*
Respiration
Sleep Wake Disorders
Uric Acid
Antioxidants
Interleukin-6
Uric Acid