J Korean Neuropsychiatr Assoc.
2003 Mar;42(2):189-193.
Possible Association between -G308A Tumor Necrosis Factor-alpha Gene Polymorphism and Major Depressive Disorder
- Affiliations
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- 1Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- 2Department of Microbiology and Immunology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Abstract
OBJECTIVES
The present study was to examine possible association between the -G308A tumor necrosis factor (TNF)-alpha gene polymorphism and major depressive disorder (MDD) in Korean.
METHODS
108 inpatients with MDD and 125 healthy controls participated in this study. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism.
RESULTS
Genotype and allele distributions in patients with MDD (p=0.02, p=0.01, respectively), were significantly different from those of the controls.
CONCLUSION
The present study suggests that the -G308A TNF-alpha gene polymorphism may have a potential role for the susceptibility to MDD in Korean population.
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