J Korean Neuropsychiatr Assoc.  2003 Mar;42(2):189-193.

Possible Association between -G308A Tumor Necrosis Factor-alpha Gene Polymorphism and Major Depressive Disorder

Affiliations
  • 1Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  • 2Department of Microbiology and Immunology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Abstract


OBJECTIVES
The present study was to examine possible association between the -G308A tumor necrosis factor (TNF)-alpha gene polymorphism and major depressive disorder (MDD) in Korean.
METHODS
108 inpatients with MDD and 125 healthy controls participated in this study. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism.
RESULTS
Genotype and allele distributions in patients with MDD (p=0.02, p=0.01, respectively), were significantly different from those of the controls.
CONCLUSION
The present study suggests that the -G308A TNF-alpha gene polymorphism may have a potential role for the susceptibility to MDD in Korean population.

Keyword

-G308A TNF-alpha gene polymorphism; Major depressive disorder

MeSH Terms

Alleles
Depressive Disorder, Major*
Genotype
Humans
Inpatients
Tumor Necrosis Factor-alpha*
Tumor Necrosis Factor-alpha
Full Text Links
  • JKNA
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
    DB Error: unknown error