Regional Cerebral Blood Flow and its Clinical Application in Patients with Ischemic Cerebrovascular Disease

Lee, Kee Hong; Kim, Dong Kun; Lim, Young Jin; Kim, Tae Sung; Kim, Gook Ki; Rhee, Bong Arm; Leem, Won

Abstract

A reliable method of measuring r-CBF should give further insight into the pathophysiology of ischemic symptom and might facilitate decisions regarding patient management. In order to study the correlation between r-CBF value and ischemic cerebrovascular disease, 80 patients who were admitted to the Department of Neurosurgery, Kyung Hee University Hospital, between January 1983 and December 1986 were evaluated by 133-Xenon inhalation method. The results were as follows: 1) There was significant decrease of CBF in patients with ischemic cerebrovascular disease than CBF of control group. 2) There was significant decrease of CBF in patients of completed stroke than TIA or RIND patient. 3) 67.5% of patients showed more decreased hemispheric value on the symptomatic side than that of opposite side. 4) r-CBF was decreased significantly in the region corresponding to each vascular territory infarction. 5) There was significantly lower CBF in patient with hematocrit in range 47 or more than in patient with hematocrit in the range 36-46. 6) Group of patients with progressing neurological manifestation showed significantly decreased CBF than that of group of patients improved. It is suggested that r-CBF measurement may be helpful for evaluation and management of the patient with ischemic cerebrovascular disease.