J Korean Neurosurg Soc.
1988 Oct;17(5):1029-1034.
Diagnosis of Cerebrovascular Disease Using 99mTc-HMPAO SPECT
- Affiliations
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- 1Department of Neurosurgery, Yonsei University, College of Medicine, Seoul, Korea.
- 2Department of Radiology, Yonsei University, College of Medicine, Seoul, Korea.
Abstract
- A new radiopharmaceutical, technetium-99m hexamethylpropyleneamine oxime(99mTc-HMPAO), has been reported to cross the blood-brain-barrier and to distribute in brain in proportion to regional blood flow. Measurement of cerebral blood flow with single photon emixxion computed tomography(SPECT) was performed using 99mTc-HMPO in 46 patients and clinical analysis was done. Decreased regional cerebral perfusion was observed in 41 cases. Moreover eight cases of them who had normal X-ray C-T scan revealed positive finding on SPECT. We porpose that 99mTc-HMPAO SPECT seems to be a useful diagnostic method for evaluation of ischemic cerebral lesions.
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