J Korean Ophthalmol Soc.  2014 Jul;55(7):978-983.

Effect of Cyclosporin A on Tear Film and Corneal Aberration after Cataract Surgery

• Jeon JH
• Kim HS
• Jung JW
• Yoon SC
• Seo KY
• Lee HK
• Kim EK
• Kim TI

Abstract

PURPOSE
To evaluate the efficacy of 0.05% cyclosporine A on tear film parameters and corneal aberration after cataract surgery.
METHODS
Patients who underwent cataract surgery were divided into 2 groups. Patients in Group I (23 eyes) were treated with cyclosporine A from 1 week before surgery to 3 months after surgery. Patients in Group II (24 eyes) underwent surgery without cyclosporine treatment. Tear film break-up time (BUT), Schirmer's test I, Oxford scheme, Ocular surface disease index (OSDI), and corneal aberrations were evaluated before surgery and at 1 and 3 months after surgery.
RESULTS
In Group I, BUT was significantly improved at 3 months (p = 0.026) after surgery compared with the preoperative value. OSDI decreased significantly at 1 (p = 0.033) and 3 months (p = 0.003) after surgery compared with the preoperative value. However, there were no significant differences between preoperative and postoperative values of BUT and OSDI in Group II. Schirmer's test results and the Oxford scheme were not significantly changed in either group. Preoperative root mean square (RMS) total values were not different between the 2 groups, but was different at postoperative 3 months (p = 0.015). Group I had a significantly lower value for total RMS than Group II. In Group I, Coma 7 (Z3(-1)) (p = 0.018) and spherical aberration (Z4(0)) (p = 0.031) were significantly decreased after surgery. In Group II, Trefoil 6 (Z3(-3)) (p = 0.033) was significantly increased after surgery.
CONCLUSIONS
0.05% cyclosporine A may be effective for improving dry eye syndrome and corneal aberration after cataract surgery.

Keyword

Cataract surgery; Corneal aberration; Cyclosporin; Dry eye

MeSH Terms

Cataract*
Coma
Cyclosporine*
Dry Eye Syndromes
Humans
Lotus
Tears*
Cyclosporine

Figure

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  Figure 1. Changes of corneal aberrations in each group during follow up. In Group I, Coma 7 (Z3-1), spherical aberration (Z40) were significantly decreased after surgery. In Group II, Trefoil 6 (Z3-3) was significantly increased after surgery. Asterisks mean p < 0.05 compared with preoperative values. RMS = root mean square; HOA = higher order aberrations.

Reference

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