J Korean Ophthalmol Soc.
2004 Sep;45(9):1547-1553.
Histologic Characteristics in the Eyes of DBA/2J Mice according to the Degree of Intraocular Pressure
- Affiliations
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- 1Department of Ophthalmology, College of Medicine, The Catholic University of Korea, Seoul, Korea. jimoon@catholic.ac.kr
- 2Apgujung St. Mary's Eye Center, Seoul, Korea.
Abstract
- PURPOSE
We assessed the correlation between ocular abnormalities and the degree of intraocular pressure (IOP) in the DBA/2J (D2) transgenic mice which were proven to have pigmentary dispersion syndrome and developing glaucoma. METHODS: Nine-months-old D2 mice were examined with biomicroscopy under anesthesia and measured for IOP by Tono-Pen, Hematoxylin and eosin staining was performed on the eye sections of the mice to analyze differences between the low-grade IOP group and the high-grade IOP group. RESULTS: Ocular abnormalities including iris pigment loss, iris transillumination, iris stromal atrophy, anterior synechia, thinning of the retina, and ganglion cell loss were found; all of which appeared to be pressure- dependent. CONCLUSIONS: These results corroborate that both IOP and age might be considered for studies using D2 mice, and suggest that D2 mice are a useful glaucoma model to study the mechanisms of retinal ganglion cell death and to evaluate strategies for neuroprotection.
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