J Korean Ophthalmol Soc.  2000 Mar;41(3):585-591.

Postoperative Suppression of Nausea and Vomiting by Preoperative Administ ration of 5-HT3 Receptor Antagonist [Granisetron]in Strabismus Surgery Under Topical Anesthesia

• Park SC
• La TY

Abstract

Traction of the extraocular muscles during strabismus surgery could cause nausea and vomiting in postoperative period. Although the extent of these symptoms would vary in wide range, sometimes they are so severe that patients may feel very uncomfortable and have difficulties with adjusting back to their routine life in immediate postoperative period. Authors have investigated whether the 5-hydroxytryptamin-3 [5HT3] receptor antagonist, which is now used as an effective antiememtic agent after general anesthesia and anticancer chemotherapy, can control the nausea and vomiting after strabismus surgery or not. As the occurrence of the oculocardiac reflex during strabismus surgery is closely related with postoperative emesis, we also examined if 5HT3 receptor antagonist can suppress the oculocardiac reflex as well. We performed strabismus surgery in 80 patients under topical anesthesia. In experimental group[N=40], 3 milligramof Granistron in 50 milliliter of normal saline was administered intravenously and in control group[N=40], the same amount of normal saline was administered one hour before the surgery. To evaluate the degree of nausea and vomiting, authors used the Rhodes 'Nausea and Vomiting Estimation Index[NVEI]and monitored heart rate for oculo-car-diac reflex. The NVEI in experimental group was 12.10 +/-5.60 compared with 16.85 +/-8.88 in control[P=0.005]. But there was no difference in frequency of oculocardiac reflex and the degree of heart rate decrement between the two groups [P=0.152, P=0.345]. In conclusion, Granisetron, 5HT3 receptor antagonist, is still effective in controlling the nausea and vomiting after strabismus surgery, but it has no suppressive effect on the oculocardiac reflex.

Keyword

5-HT3 receptor antagonist[Granisetron]; Nausea and vomiting; Strabismus surgery

MeSH Terms

Anesthesia*
Anesthesia, General
Drug Therapy
Granisetron
Heart Rate
Humans
Muscles
Nausea*
Postoperative Nausea and Vomiting
Postoperative Period
Receptors, Serotonin, 5-HT3*
Reflex
Reflex, Oculocardiac
Strabismus*
Traction
Vomiting*
Granisetron
Receptors, Serotonin, 5-HT3