Korean J Anesthesiol.  2005 Oct;49(4):507-512. 10.4097/kjae.2005.49.4.507.

Ramosetron Compared with Granisetron for the Prevention of Postoperative Nausea and Vomiting following General Anesthesia for Breast Mass Excision

• Kim JE
• Lee CB
• Kim SC
• Kim SI
• Ok SY

• KMID: 1936852
• DOI: http://doi.org/10.4097/kjae.2005.49.4.507

Abstract

BACKGROUND: Women undergoing general anesthesia for breast mass excision have a high risk for postoperative nausea and vomiting (PONV). We therefore evaluated the efficacy of ramosetron versus granisetron for preventing PONV.
METHODS
One hundred twenty women scheduled for breast mass excision received, in a randomized allocated, double-blind manner, an intravenous placebo (P group), granisetron 40microgram/kg (G group) or ramosetron 6 microgram/kg (R group) at the end of surgery. Emetic episode and side effects were assessed.
RESULTS
The incidence and severity of nausea in G and R group was less than P group (P<0.05) during the first 24 hrs. The incidence of vomiting in R group was less than P group (P<0.05) during the first 6 hrs. However there was no significant difference in the incidence of PONV between G and R group.
CONCLUSIONS
Our results showed that both granisetron and ramosetron significantly decreased the occurrence of PONV compared to placebo. However, any different efficacy for preventing PONV was not revealed between granisetron and ramosetron.

Keyword

breast surgery; granisetron; postoperative nausea and vomiting; ramosetron

MeSH Terms

Anesthesia, General*
Breast*
Female
Granisetron*
Humans
Incidence
Nausea
Postoperative Nausea and Vomiting*
Vomiting
Granisetron