J Korean Pediatr Soc.  1994 Apr;37(4):553-559.

Furosemide-Induced Nephrocalcinosis in Very Low Birth Weight Infants

• Park MJ
• Park KI
• Park MS
• Namgung R
• Lee C
• Han DG
• Yim H
• Jung WH

Abstract

Renal calcifications are a recognized complication of furosemide therapy in premature infants. Particularly in infants with chronic lung disease, the use of this potent diuretic is associated with hypercalciuria, which may predispose the infant to medullary nephrocalcinosis and renal calculi, We experienced two cases of nephrocalcinosis in very low birth weight infants. One had bronchopulmonary dysplasia, pneumonia, patent ductus arteriosus, ventricular septal defect and congestive heart failure and the other had systemic cytomegalovirus infection with cytomegalovirus pneumonitis and ricket of prematurity. Both patients received a large amount of furosemide. We presented these cases with brief review of literatures.

MeSH Terms

Bronchopulmonary Dysplasia
Cytomegalovirus
Cytomegalovirus Infections
Ductus Arteriosus, Patent
Furosemide
Heart Failure
Heart Septal Defects, Ventricular
Humans
Hypercalciuria
Infant*
Infant, Newborn
Infant, Premature
Infant, Very Low Birth Weight*
Kidney Calculi
Lung Diseases
Nephrocalcinosis*
Pneumonia
Furosemide