J Korean Soc Endocrinol.  1998 Sep;13(3):466-472.

A Case with Multifocal Langerhans Cell Granulomatosis Involving the Thyroid Gland

• Lee KW
• Chung CK
• Hwang SC
• Yim HH
• Park SY
• Lee SK
• Chung YS
• Kim HM
• Kim YJ
• Hong EK
• Chae BN

Abstract

Langerhans cell granulomatosis(LCG), previously termed 'Histiocytosis-X', is one of the rare disease. LCG is characterized by proliferation of Langerhans cells in a unifocal or multifocal pattern. And LCG may be manifested in a variety of way, ranging from a spontaneously regressing solitary lesion to a multisystem life-threatening disorder. This disease usually involves the bone, lung, skin and lymph node. The most common endocrinologic abnormalities in LCG are diabetes insipidus and growth hormone deficiency. LCG involving the thyroid gland is extremely rare and only a small numbers of cases have been reported worldwide. A 41-year-old diabetic female visited the hospital due to the neck swelling for 3 months and she also complained of polyuria, polydipsia and easy fatigue. LCG involving multiple organs included thyroid gland was diagnosed by high-resolution CT of lung, by characteristic histological findings of the thyroid lesion and by the immunohistochemical staining for S-100 protein and OKT 6(CD la). She is followed at OPD without any medication.

MeSH Terms

Adult
Diabetes Insipidus
Fatigue
Female
Growth Hormone
Histiocytosis, Langerhans-Cell*
Humans
Langerhans Cells
Lung
Lymph Nodes
Neck
Polydipsia
Polyuria
Rare Diseases
S100 Proteins
Skin
Thyroid Gland*
Growth Hormone
S100 Proteins