Endocrinol Metab.  2012 Jun;27(2):138-141. 10.3803/EnM.2012.27.2.138.

Langerhans Cell Histiocytosis in the Thyroid and Draining Lymph Nodes: A Case Report

  • 1Department of Pathology, Gachon University School of Medicine, Incheon, Korea.
  • 2Department of Surgery, Gachon University School of Medicine, Incheon, Korea.
  • 3Department of Pathology, Ewha Womans University School of Medicine, Seoul, Korea. spark0430@ewha.ac.kr


A 53-year-old woman was presented with several 0.3-0.6 cm-sized nodules within the right lobe of the thyroid. Histologic sections of the thyroid demonstrated multiple papillary microcarcinomas in the background of lymphocytic thyroiditis, with a small focus of Langerhans cell histiocytosis (LCH). Small LCH nodules were also found in the draining cervical lymph nodes. Although the association of LCH with papillary thyroid carcinoma in the thyroid has been reported, their co-existence with LCH in the draining lymph nodes is very rare.


Langerhans cell histiocytosis; Thyroid papillary carcinoma; Thyroid gland
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