J Korean Assoc Oral Maxillofac Surg.  2010 Dec;36(6):533-537.

Sialadenoma papilliferum: a case report and immunohistochemical study review

• Byun JH
• Kim DC
• Go GH
• Park BW

Abstract

Sialadenoma papilliferum (SP) is a rare benign neoplasm that normally arises from the minor salivary glands, particularly in the palate. SP is normally encountered in older men with an exophytic papillary surface growth. In the present study, an SP of the hard palate of a 69-year-old woman was examined immunohistochemically. Myoepithelial cell markers, such as S-100, smooth muscle actin and vimentin, were observed in the basal or luminal layer of tumor cells, indicating that myoepithelial cells participate in the pathogenesis of SP. In addition, cytokeratin 7 was also strongly detected in the tumor cells, suggesting that excretory ductal epithelial cells have a role in its histogenesis. A review of the literature of immunohistochemical studies on SP showed that the expression and co-expression of cytokeratins and myoepithelial cell markers have been reported in tumor cells. These results suggested that excretory duct cells and myoepithelial cells participate in the pathogenesis of SP.

Keyword

Sialadenoma papilliferum; Hard palate; Immunohistochemistry

MeSH Terms

Actins
Aged
Epithelial Cells
Female
Humans
Immunohistochemistry
Keratin-7
Keratins
Male
Muscle, Smooth
Palate
Palate, Hard
Phenobarbital
Salivary Glands, Minor
Vimentin
Actins
Keratin-7
Keratins
Phenobarbital
Vimentin

Figure

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  Fig. 1. Perioperative radiologic and clinical features. A. In preoperative MRI view, well demarcated firm mass was observed under the palatal mucosa (white arrow). B. After removal of tumor, intact hard palatal bone was detected. C. Main mass (∗), approximately 1.5x1 cm size, was resected with peripheral normal tissues. D. After 6 months of operation, completely healed palatal mucosa was observed. (MRI: magnetic resonance imaging)

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  Fig. 2. Photomicrograph of the lesion.(H&E staining) A. The central portion of the tumor was contained hyperplastic squamous epithelium connected to surface mucosa, whereas the remaining tumor showed glandular (arrow) and projecting papillary portion (arrowhead).(original magnification x12) B. Ductal proliferation and dilation with papillary folds were observed in the glandular portion under moderate magnification. (original magnification x40) C. High magnification image of a region showing papillary projection. Papillary fronds were lined by a double row of cells composed of luminal columnar cells and short cuboidal or basaloid cells.(original magnification x200) D. High magnification glandular portion. Some mucin-secreting cells (arrow) were occasionally observed among lining columnar cells of the dilated duct (original magnification x200)

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  Fig. 3. Immunohistochemical findings of the lesion. A, B. CK 7 was strongly expressed, but CK20 was absent in tumor cells.(original magnification x100) C. S-100 protein was moderately expressed in tumor cell luminal and basal layers.(original magnification x100) D. SMA was strongly expressed in the basal layer of tumor cells (arrow), but was not observed in the luminal columnar cells.(original magnification x200) E. Vimentin was weakly expressed in the basal layer of tumor cells.(original magnification x200) F. CEA expression was not observed in any tumor cell layer. (original magnification x100) (CK7: cytokeratin 7, CK20: cytokeratin 20, S-100: S-100 protein, SMA: smooth muscle actin, CEA: carcinoembryonic antigen)

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