J Korean Assoc Pediatr Surg.  2016 Jun;22(1):14-17. 10.13029/jkaps.2016.22.1.14.

A Pediatric Case of Mixed Acinar-Neuroendocrine Carcinoma

• Youn JK
• Son HE
• Jung SE
• Kim HY

• KMID: 2327656
• DOI: http://doi.org/10.13029/jkaps.2016.22.1.14

Abstract

Mixed acinar-neuroendocrine carcinoma (MANEC) is a malignant pancreatic tumor that rarely occurs in children. It is diagnosed pathologically according to the proportion of neuroendocrine cells present, highlighting the need for surgical biopsy. A 13-year-old boy presented with a 10-cm palpable mass on CT. Surgical resection was performed, and the pathological diagnosis was MANEC. There were no postoperative complications, and the patient was discharged from the hospital 10 days after surgery. He is presently undergoing adjuvant chemotherapy. We reviewed historical MANEC cases published in the English literature. We concluded that pathological analysis of a surgically resected specimen is necessary for an accurate diagnosis of MANEC, and that publication of more cases is needed to determine the optimal management strategy for MANEC.

Keyword

Neuroendocrine carcinoma; Acinar cell carcinoma; Operative surgical procedures; Immunocytochemistry

MeSH Terms

Adolescent
Biopsy
Carcinoma, Acinar Cell
Carcinoma, Neuroendocrine
Chemotherapy, Adjuvant
Child
Diagnosis
Humans
Immunohistochemistry
Male
Neuroendocrine Cells
Postoperative Complications
Publications
Surgical Procedures, Operative