Radiat Oncol J.  2016 Jun;34(2):113-120. 10.3857/roj.2016.01725.

Association between obesity and local control of advanced rectal cancer after combined surgery and radiotherapy

• Choi Y
• Lee YH
• Park SK
• Cho H
• Ahn KJ

• KMID: 2327384
• DOI: http://doi.org/10.3857/roj.2016.01725

Abstract

PURPOSE
The association between metabolism and cancer has been recently emphasized. This study aimed to find the prognostic significance of obesity in advanced stage rectal cancer patients treated with surgery and radiotherapy (RT).
MATERIALS AND METHODS
We retrospectively reviewed the medical records of 111 patients who were treated with combined surgery and RT for clinical stage 2-3 (T3 or N+) rectal cancer between 2008 and 2014. The prognostic significance of obesity (body mass index [BMI] ≥25 kg/m²) in local control was evaluated.
RESULTS
The median follow-up was 31.2 months (range, 4.1 to 85.7 months). Twenty-five patients (22.5%) were classified as obese. Treatment failure occurred in 33 patients (29.7%), including local failures in 13 patients (11.7%), regional lymph node failures in 5, and distant metastases in 24. The 3-year local control, recurrence-free survival, and overall survival rates were 88.7%, 73.6%, and 87.7%, respectively. Obesity (n = 25) significantly reduced the local control rate (p = 0.045; 3-year local control, 76.2%), especially in women (n = 37, p = 0.021). Segregation of local control was best achieved by BMI of 25.6 kg/m² as a cutoff value.
CONCLUSION
Obese rectal cancer patients showed poor local control after combined surgery and RT. More effective local treatment strategies for obese patients are warranted.

Keyword

Obesity; Rectal cancer; Radiotherapy; Local control; Prognosis

MeSH Terms

Female
Follow-Up Studies
Humans
Lymph Nodes
Medical Records
Metabolism
Neoplasm Metastasis
Obesity*
Prognosis
Radiotherapy*
Rectal Neoplasms*
Retrospective Studies
Survival Rate
Treatment Failure