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How to Combine Diffusion-Weighted and T2-Weighted Imaging for MRI Assessment of Pathologic Complete Response to Neoadjuvant Chemoradiotherapy in Patients with Rectal Cancer?

Jang JK, Lee Cm, Park SH, Kim JH, Kim J, Lim SB, Yu CS, Kim JC

Objective: Adequate methods of combining T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI) to assess complete response (CR) to chemoradiotherapy (CRT) for rectal cancer are obscure. We aimed to determine an...
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Neorectal Mucosal Prolapse After Intersphincteric Resection for Low-Lying Rectal Cancer: A Case Report

Alessa M, Bae HW, Alawfi H, Sakr A, Sauri F, Kim NK

Radical resection for low rectal cancer is the mainstay among the treatment modalities. Intersphincteric resection (ISR) is considered a relatively new but effective surgical treatment for low-lying rectal tumor. As...
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Clinical characteristics and survival of colorectal cancer patients in Korea stratified by age

Baek SK, Lee JS, Hwang IG, Kim JG, Kim TW, Sohn SK, Kang MY, Lee SC

Background/Aims: This nationwide study was undertaken to determine differences in clinicopathologic characteristics and survival of patients with colorectal cancer (CRC) according to age using big data from the Korean National...
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LASSO-Based Machine Learning Algorithm for Prediction of Lymph Node Metastasis in T1 Colorectal Cancer

Kang J, Choi YJ, Kim Ik, Lee HS, Kim H, Baik SH, Kim NK, Lee KY

Purpose The role of tumor-infiltrating lymphocytes (TILs) in predicting lymph node metastasis (LNM) in patients with T1 colorectal cancer (CRC) remains unclear. Furthermore, clinical utility of a machine learning–based approach...
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Current approaches in intensification of long-course chemoradiotherapy in locally advanced rectal cancer: a review

Haddad P, Ghalehtaki R, Saeedian A, Farhan F, Babaei M, Aghili M

Rectal cancer is one of the most prevalent cancers in the world. In many countries, the current standard of care is long-course chemoradiation (CRT), followed by total mesorectal excision. Some...
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Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Obstructing Colorectal Cancer Treated by Endoscopic Stenting as a Bridge to Surgery

Guo J, Chok AY, Lim HJ, Tay WX, Lye WK, Samarakoon LB, Tan EJ, Mathew R

Purpose: Neutrophil-to-lymphocyte ratio (NLR) has been reported to predict adverse survival outcomes among patients with colorectal cancer (CRC). This study evaluates the prognostic value of NLR among patients with obstructing...
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Characteristics of Patients Presented With Metastases During or After Completion of Chemoradiation Therapy for Locally Advanced Rectal Cancer: A Case Series

Torky R, Alessa M, Kim HS, Sakr A, Zakarneh E, Sauri F, Bae H, Kim NK

Purpose: Locally advanced rectal cancer (LARC) is managed by chemoradiotherapy (CRT), followed by surgery. Herein we reported patients with metastases during or after CRT. Methods: Data of patients with LARC who...
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Inhibition of COX-2 Impairs Colon Cancer Liver Metastasis through Reduced Stromal Cell Reaction

Herrero A, Benedicto A, Romayor I, Olaso E, Arteta B

Liver colonization is initiated through the interplay between tumor cells and adhesion molecules present in liver sinusoidal endothelial cells (LSECs). This crosstalk stimulates tumor COX-2 upregulation and PGE 2 secretion....
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Food intake and its effect on the species and abundance of intestinal flora in colorectal cancer and healthy individuals

Shen W, Sun J, Li Z, Yao F, Lin K, Jiao X

Background/Aim: It is known that an imbalance in the intestinal f lora plays a crucial role in colorectal cancer (CRC), but the effect of food consumption patterns on the types...
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Clinical practice guideline for endoscopic resection of early gastrointestinal cancer

Park CH, Yang DH, Kim JW, Kim JH, Kim JH, Min YW, Lee SH, Bae JH, Chung H, Choi KD, Park JC, Lee H, Kwak MS, Kim B, Lee HJ, Lee HS, Choi M, Park DA, Lee JY, Byeon JS, Park CG, Cho JY, Lee ST, Chun HJ

Although surgery was the standard treatment for early gastrointestinal cancers, endoscopic resection is now a standard treatment for early gastrointestinal cancers without regional lymph node metastasis. High-definition white light endoscopy,...
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Dysregulated Free Fatty Acid Receptor 2 Exacerbates Colonic Adenoma Formation in ApcMin/+ Mice: Relation to Metabolism and Gut Microbiota Composition

Huang YW, Lin CW, Pan P, Echeveste CE, Dong A, Oshima K, Yearsley M, Yu J, Wang LS

Free fatty acid receptor 2 (FFAR2) has been reported as a tumor suppressor in colon cancer development. The current study investigated the effects of FFAR2 signaling on energy metabolism and...
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Optimal Complete Rectum Mobilization Focused on the Anatomy of the Pelvic Fascia and Autonomic Nerves: 30 Years of Experience at Severance Hospital

Kim NK, Kim HS, Alessa M, Torky R

The primary goal of surgery for rectal cancer is to achieve an oncologically safe resection, i.e., a radical resection with a sufficient safe margin. Total mesorectal excision has been introduced...
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Sex difference in bowel preparation quality and colonoscopy time

Hwang YJ, Shin DW, Kim N, Yoon H, Shin CM, Park YS, Lee DH

Background/Aims: The length of colon is known to be longer in females than in males. In addition, the morphology of colon cancer is different between males and females. The aim...
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Short- and mid-term outcomes of transanal versus laparoscopic total mesorectal excision for low rectal cancer: a meta-analysis

Ren J, Luo H, Liu S, Wang B, Wu F

Purpose: The current meta-analysis combining mid and low rectal cancer with no meta-analysis only for low rectal cancer was seen. This meta-analysis was to compare the short- and mid-term outcomes...
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The Relationship Between High-Output Stomas, Postoperative Ileus, and Readmission After Rectal Cancer Surgery With Diverting Ileostomy

Lee N, Lee SY, Kim CH, Kwak HD, Ju JK, Kim HR

Purpose: This study aimed to evaluate the relationship between high-output stomas (HOSs), postoperative ileus (POI), and readmission after rectal cancer surgery with diverting ileostomy. Methods: We included 302 patients with rectal...
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Prognostic implication of systemic inflammatory markers in young patients with resectable colorectal cancer

Lee Sy, Lee SI, Min BW, Oh SC

Purpose: The prognosis of young colorectal cancer (CRC) patients has not fully been addressed. The prognostic significance of systemic inflammatory markers was examined in those patients. Methods: A total of 965...
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Robotic pelvic exenteration and extended pelvic resections for locally advanced or synchronous rectal and urological malignancy

Williams M, Perera M, Nouhaud FX, Coughlin G

Purpose: To describe the surgical technique and examine the feasibility and outcomes following robotic pelvic exenteration and extended pelvic resection for rectal and/or urological malignancy. Materials and Methods: We present a...
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Trends of Colorectal Cancer Prevalence in Kazakhstan Related to Screening

Zhylkaidarova A, Kaidarova D, Batyrbekov K, Shatkovskaya O, Begimbetova D

We carried out an analysis of the total incidence of colon cancer throughout Kazakhstan. Retrospectively, according to the regional reports on endoscopic screening, the study showed an increase in the...
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Feasibility of Single-Incision Plus One Port Laparoscopic Low Anterior Resection for Rectal Cancer

Kwak JY, Yang KM, Han MS

Purpose: Single-incision laparoscopic surgery is a recently developed minimally invasive surgical technique. We aimed to compare the feasibility and safety of single-incision plus one port laparoscopic low anterior resection (S+1-LAR)...
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The Usefulness of Preoperative Colonoscopic Tattooing with Autologous Blood for Localization in Laparoscopic Colorectal Surgery

Yeo UD, Sung NS, Roh SJ, Choi WJ, Song KH, Choi IS, Yoon DS, Lee SE, Moon JI, Kwon SU, Bae IE, Lee SJ

Purpose: In colorectal cancer surgery, it is important to have accurate resection margins. However, it is challenging to localize lesions during laparoscopy. Therefore, to reduce surgical errors, many preoperative localizing...
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