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Management of isolated para-aortic lymph node recurrence after surgery for colorectal cancer

Kim YI, Park IJ, Park JH, Kim TW, Ro JS, Lim SB, Yu CS, Kim JC

PURPOSE: The rare incidence of isolated para-aortic lymph node (PALN) recurrence of colorectal cancer has precluded the formulation of treatment guidelines. This study evaluated and compared the effects of different...
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Upregulated Long Noncoding RNA LINC01234 Predicts Unfavorable Prognosis for Colorectal Cancer and Negatively Correlates With KLF6 Expression

Jiang X, Zhu Q, Wu P, Zhou F, Chen J

BACKGROUND: LINC01234, a long noncoding RNA (lncRNA), is overexpressed in several cancers, including colorectal cancer (CRC). We investigated the role of LINC01234 in CRC development and confirmed its correlation with...
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Gastric and rectal cancers in workers exposed to asbestos: a case series

Choi BJ, Lee S, Lee IJ, Park SW, Lee S

BACKGROUND: The Occupational Safety and Health Research Institute (OSHRI) of the Korea had not recognized gastrointestinal cancer as work-related disease during their evaluation. However, in 2018 OSHRI recognized gastric and...
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Clinical Impact of Myeloid-Derived Suppressor Cells, Lymphocyte Subsets, and Neutrophil-to-Lymphocyte Ratio in Patients with Colorectal Cancer

Kang MG, Kim CH, Kim SH, Shin JH, Kim HR, Shin MG

BACKGROUND: Preoperative myeloid-derived suppressor cells (MDSCs), neutrophil-to-lymphocyte ratio (NLR), and lymphocyte subsets have been reported to be associated with the clinical outcomes in colorectal cancer (CRC). However, studies on the...
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Patterns of antibiotics and pathogens for anastomotic leakage after colorectal cancer surgery

Yang G, Kim CW, Lee SH

PURPOSE: Anastomotic leakage (AL) is a type of intra-abdominal infection (IAI) which requires appropriate antibiotics with proper intervention. This study aimed to improve the appropriateness of antibiotic treatment by assessing...
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Mucinous carcinoma is a predictive factor for the risk of open conversion from laparoscopic colectomy in colorectal cancer

Seo AJ, Shin JK, Park YA, Huh JW, Cho YB, Kim HC, Yun SH, Lee WY

PURPOSE: Although laparoscopic surgery is widely accepted in the treatment of colorectal cancer, conversion to open surgery is associated with the rate of unfavorable outcomes. The aim of this study...
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Robotic Surgery for Rectal Cancer and Cost-Effectiveness

Jeon Y, Park EJ, Baik SH

Robotic surgery is considered as one of the advanced treatment modality of minimally invasive surgery for rectal cancer. Robotic rectal surgery has been performed for three decades and its application...
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Detection of KRAS mutations in plasma cell-free DNA of colorectal cancer patients and comparison with cancer panel data for tissue samples of the same cancers

Min S, Shin S, Chung YJ

Robust identification of genetic alterations is important for the diagnosis and subsequent treatment of tumors. Screening for genetic alterations using tumor tissue samples may lead to biased interpretations because of...
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Risk Factors for Colorectal Cancer in Korea: A Population-Based Retrospective Cohort Study

Nam S, Choi YJ, Kim DW, Park EC, Kang JG

PURPOSE: The incidence of colorectal cancer in Korea has recently increased, making it the second most common cancer in men and the third most common cancer in women. Risk factors...
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Immunological Differences Between Right-Sided and Left-Sided Colorectal Cancers: A Comparison of Embryologic Midgut and Hindgut

Kwak HD, Ju JK

PURPOSE: There are known differences in embryology, clinical symptoms, incidences, molecular pathways involved, and oncologic outcomes of right-sided and left-sided colorectal cancers. However, immunologic study has only been characterized for...
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Impact of Adjuvant Chemotherapy Completion on Oncologic Outcomes in ypTNMstage 2 Rectal Cancer Patients

Park YY, Lee KY, Kim NK, Lee SB, Kim GR, Min BS, Oh ST

PURPOSE: Adjuvant chemotherapy (aCT) in rectal cancer patients who have undergone curative resection after neoadjuvant chemoradiation (nCRT) is controversial. We aimed to investigate the benefits of using aCT and the...
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Analysis of Intestinal Mucosal Microbiome Changes before and after Chemoradiation in Locally Advanced Rectal Cancer Patients

Seo I, Bae SU, Kim S, Jeong WK, Baek SK

PURPOSE: Dysbiosis of gut microbiota has been reported to participate in the pathogenesis of colorectal cancer, but changes in microbiota due to radiotherapy have not been studied. In this study,...
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Development and Evaluation of Enhanced Recovery After Surgery Program for Patients with Colorectal Cancer Surgery

Kim EJ, Park JS

PURPOSE: This study aimed to develop and evaluate the effectiveness of the Enhanced Recovery After Surgery (ERAS) program for colorectal cancer surgery patients. METHODS: This program was developed using ADDIE model....
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Evaluating the recent developments in palliative chemotherapy for metastatic colorectal cancer

Baek SK, Lee KT, Bae SB, Lee SC

The incidence of colorectal cancer (CRC) has increased. CRC is the third most common cancer and the fourth most common cause of cancer-related deaths in Korea. Palliative chemotherapy can be...
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Operative safety and oncologic outcomes in rectal cancer based on the level of inferior mesenteric artery ligation: a stratified analysis of a large Korean cohort

AlSuhaimi , Yang SY, Kang JH, AlSabilah , Hur H, Kim NK

PURPOSE: To compare high and low inferior mesenteric artery (IMA) ligation in a large number of patients, and investigate the short-term and long-term outcomes. METHODS: This retrospective study compared outcomes between...
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Hepatic resection after neoadjuvant chemotherapy for patients with liver metastases from colorectal cancer: need for cautious planning

Kim YI, Park IJ, Kim JE, Kim SY, Park JH, Lee JH, Ha TY, Hong YS, Kim SY, Kim TW, Lim SB, Yu CS, Kim JC

PURPOSE: Current neoadjuvant chemotherapy (NAC) may enable therapies such as surgical resection and local ablation of metastases in patients with colorectal liver metastasis (CLM). We evaluated outcomes in CLM patients...
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Parthenolide inhibits transforming growth factor β1-induced epithelial-mesenchymal transition in colorectal cancer cells

Zhu SM, Park YR, Seo SY, Kim IH, Lee ST, Kim SW

BACKGROUND/AIMS: Transforming growth factor-β1 (TGF-β1) induction of epithelial-mesenchymal transition (EMT) is one of the mechanisms by which colorectal cancer (CRC) cells acquire migratory and invasive capacities, and subsequently metastasize. Parthenolide...
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Sensitivity of Various Evaluating Modalities for Predicting a Pathologic Complete Response After Preoperative Chemoradiation Therapy for Locally Advanced Rectal Cancer

Jung S, Parajuli A, Yu CS, Park SH, Lee JS, Kim AY, Lee JL, Kim CW, Yoon YS, Park IJ, Lim SB, Kim JC

PURPOSE: We investigated the sensitivity of various evaluating modalities in predicting a pathologic complete response (pCR) after preoperative chemoradiation therapy (PCRT) for locally advanced rectal cancer (LARC). METHODS: From a population...
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Efficacy and Feasibility of Adding Induction Chemotherapy to Neoadjuvant Chemoradiation in Locally Advanced Rectal Cancer: A Phase II Clinical Trial

Nasrolahi , Mirzaei S, Mohammadianpanah M, Bananzadeh AM, Mokhtari M, Sasani MR, Mosalaei A, Omidvari S, Ansari M, Ahmadloo N, Hamedi SH, Khanjani N

PURPOSE: Currently, neoadjuvant chemoradiation (CRT) followed by total mesorectal resection is considered the standard of care for treating locally advanced rectal cancer. This study aimed to investigate the efficacy and...
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Predictors of Quality of Life and Social Support as a Mediator between Defecation Function and Quality of Life among Rectal Cancer Patients

Kim JR, Hwang SY

PURPOSE: To identify the factors influencing Quality of Life (QoL) in rectal cancer patients and to examine whether perceived social support mediates the relationship between defecation function and QoL. METHODS: Using self-report...
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