J Korean Acad Rehabil Med.  2010 Dec;34(6):670-676.

Risk Factors of Critical Illness Polyneuropathy on Intensive Care Unit Patients

• Hong JY
• Kim JK
• Rah UW
• Yoon SH
• Lee YJ

Abstract

OBJECTIVE
To find the risk factors of critical illness polyneuropathy (CIP) on intensive care unit patients using early electrodiagnosis. METHOD: The adult patient who were admitted to the ICU and taken ventilator care with endotracheal intubation were included. The time after admission was 48 to 144 hours. In case of axonal neuropathy of peripheral nerve, if affected nerves were in different two limbs or different three nerves were affected, CIP was diagnosed. If some nerves got abnormal results but did not satisfied the above criteria, the patient was classified as peripheral neuropathy group. The days of using neuromuscular blockade, continuous insulin infusion, catecholamine, vasopressor, corticosteroid, benzodiazepine, parenteral nutrition and fact for continuous renal replacement therapy, SOFA (sequential organ failure assessment) score were evaluated to find the risk factors.
RESULTS
Eighteen patients were included. Six patients were CIP and another six were peripheral neuropathy. Risk factors for CIP were age, duration of intensive care, days of neuromuscular blockade and parenteral nutrition (p<0.05). There was no difference on mortality rate among the three groups.
CONCLUSION
The result of early electrodiagnosis on ICU patients for CIP diagnosis revealed that risk factors of CIP were age, duration of intensive care, days of neuromuscular blockade and parenteral nutrition.

Keyword

Critical illness polyneuropathy; Risk factor; Electrodiagnosis

MeSH Terms

Adult
Axons
Benzodiazepines
Critical Illness
Electrodiagnosis
Extremities
Humans
Insulin
Critical Care
Intensive Care Units
Intubation, Intratracheal
Neuromuscular Blockade
Parenteral Nutrition
Peripheral Nerves
Peripheral Nervous System Diseases
Polyneuropathies
Renal Replacement Therapy
Risk Factors
Ventilators, Mechanical
Benzodiazepines
Insulin