J Korean Acad Rehabil Med.  2008 Oct;32(5):586-590.

Persistent Autonomic Dysfunction in Guillain-Barre Syndrome: A case report

• Lee SJ
• Choi ES
• Jung SH
• Cho YR
• Han ZA
• Yu IH

Abstract

Autonomic dysfunction is a common manifestation in Guillain-Barre syndrome (GBS), but it rarely persists. We report a case involving a 22-year-old man who presented with glove-and-stocking type sensory loss, symmetric weakness, urinary distension, orthostatic hypotension, decreased perspiration, and the syndrome of inappropriate secretion of antidiuretic hormone. He was subsequently diagnosed as having GBS with autonomic failure that persisted for more than six months, despite regaining muscle strength. Orthostatic hypotension progressively improved after rehabilitation and administration of midodrine and fludrocortisone. Extensive evaluation and management should be performed in patients with GBS because severe autonomic dysfunction is a major source of disability.

Keyword

Autonomic dysfunction; Orthostatic hypotension; Guillain-Barre syndrome

MeSH Terms

Fludrocortisone
Guillain-Barre Syndrome
Humans
Hypotension, Orthostatic
Midodrine
Muscle Strength
Young Adult
Fludrocortisone
Midodrine