J Korean Surg Soc.  2002 Nov;63(5):429-431.

Glycogen-Rich Clear Cell Carcinoma of the Breast

• Lee YY
• Kim JM
• Kim SJ
• Cho YU
• Shin SH
• Kim KR

Abstract

Glycogen-rich clear cell carcinoma of the breast is a very rare malignancy whose incidence is about 1~3% of the total breast cancers. Histologic features are usually those of ductal carcinoma, but it contains the cells that is characterized by the abundant cytoplasm and centrally-located nuclei. We report a case of glycogen-rich clear cell carcinoma of the breast. The case is a 63-year-old woman with a palpable lump of the right breast. The operation is partial mastectomy with axillary lymph node dissection. The tumor consists of round or polygonal cells. The cell membranes are distinct, and the cytoplasm is clear. Most of the nulcei are centrally-located and hyperchromatic. The tumor cells are PAS positive and D-PAS negative. Immunohistochemically, the tumor cells are positive to the epithelial membrane antigen (EMA), and negative to vimentin, smooth muscle actin, desmin. Estrogen receptors are positive, but progesterone receptors are negative.

Keyword

Breast; Glycogen-rich clear cell carcinoma

MeSH Terms

Actins
Breast*
Carcinoma, Ductal
Cell Membrane
Cytoplasm
Desmin
Female
Humans
Incidence
Lymph Node Excision
Mastectomy, Segmental
Middle Aged
Mucin-1
Muscle, Smooth
Receptors, Estrogen
Receptors, Progesterone
Vimentin
Actins
Desmin
Mucin-1
Receptors, Estrogen
Receptors, Progesterone
Vimentin