J Breast Cancer.  2012 Mar;15(1):135-138. 10.4048/jbc.2012.15.1.135.

Intraductal Lipid-Rich Carcinoma of the Breast with a Component of Glycogen-Rich Carcinoma

• Kurisu Y
• Tsuji M
• Shibayama
• Takahashi
• Nohara T

• KMID: 2286487
• DOI: http://doi.org/10.4048/jbc.2012.15.1.135

Abstract

We report a rare case of intraductal lipid-rich carcinoma of the breast with a component of glycogen-rich carcinoma. An impalpable tumor that was revealed by mammography and magnetic resonance imaging was excised. Histologic examination showed vacuolated neoplastic cells in the mammary ducts, and electron microscopy confirmed lipid droplets in the cytoplasm. The coexistence of glycogen-rich carcinoma was shown. Lipid-rich carcinoma that is coexistent with glycogen-rich carcinoma is rare, and most lipid-rich carcinomas are invasive. Intraductal lipid-rich carcinoma is difficult to detect without echography or mammography.

Keyword

Breast carcinoma; Glycogen; Immunohistochemistry; Lipid

MeSH Terms

Breast
Cytoplasm
Glycogen
Immunohistochemistry
Magnetic Resonance Imaging
Mammography
Microscopy, Electron
Glycogen

Figure

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  Figure 1 Mammography findings. Multiple small linear calcifications are seen in the left breast.

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  Figure 2 The border of the tumor is unclear, and mass formation is not observed (H&E stain, ×1).

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  Figure 3 (A) Intraductal lipid-rich carcinoma. Neoplastic cells with vacuolated cytoplasms fill the mammary ducts. A comedo pattern with central necrosis is seen (H&E stain, ×100). (B) Electron microscopy showed lipid droplets (arrows) in the cytoplasm of tumor cells.

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  Figure 4 A component of glycogen-rich carcinoma (A, H&E stain, ×200; B, periodic acid-Schiff stain [PAS], ×200; C, PAS after diastase digestion, ×200). Cells with a small round nucleus and eosinophilic cytoplasm (A) are positive for periodic acid-Schiff stain (B), after treatment of diastase, negative for PAS (C).

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