J Korean Surg Soc.  2012 May;82(5):296-301.

Is there a relationship between beginning time and efficiency of octreotide in the treatment of experimental acute pancreatitis?

Affiliations
  • 1Department of Surgery, Selcuklu Medical Faculty, Selcuk University, Konya, Turkey. halptekin@hotmail.com
  • 2Department of Emergency Medicine, Meram Medical Faculty, Selcuk University, Konya, Turkey.
  • 3Department of Pathology, Meram Medical Faculty, Selcuk University, Konya, Turkey.
  • 4Department of Biochemistry, Meram Medical Faculty, Selcuk University, Konya, Turkey.

Abstract

PURPOSE
The efficacy of octreotide in the treatment of acute pancreatitis is controversial. Octreotide treatment for acute pancreatitis often shows poor correlation between results obtained in experimental studies and results of clinical trials. In a clinical setting, there is always a delay between the onset of the disease and initiation of the octreotide treatment. The aim of this study is to investigate the relationship between the beginning of treatment and alteration in effectiveness of octreotide.
METHODS
Acute pancreatitis was induced by pancreatic duct ligation in 50 rats. The rats were randomly divided into five groups. Octreotide was not used in group 1 (control group). Only single dose (4 microg/kg) octreotide was administered subcutaneously to rats in group 2, having induced pancreatitis. Octreotide treatment was begun at different times (8th, 24th, 48th hour) in three other groups and continued treatment at a dosage of 4 microg/kg t.i.d. The animals were sacrificed at the end of the 72nd hour and blood and tissue samples were collected.
RESULTS
Leukocyte count and plasma amylase values were less in groups 2 and 3. Hemorrhagic focuses were encountered less at pancreas tissues in group 3. Pancreatic necrosis and alveolar capillary basal membrane damage were lower in groups 3 and 4. No difference was found in fasting blood glucose, calcium and hematocrit.
CONCLUSION
Octreotide had benefical effects in acute pancreatitis when octreotide treatment was begun in the first 24 hours.

Keyword

Pancreatitis; Octreotide; Amylase

MeSH Terms

Amylases
Animals
Blood Glucose
Calcium
Capillaries
Fasting
Leukocyte Count
Ligation
Membranes
Necrosis
Octreotide
Pancreas
Pancreatic Ducts
Pancreatitis
Plasma
Rats
Amylases
Blood Glucose
Calcium
Octreotide

Figure

  • Fig. 1 Amylase levels and degree of histopathological changes that were found to differ between groups. Error bars denote Standard deviation (SD). (A) Amylase levels. (B) Pancreatic haemorrhagia. (C) Pancreatic necrosis. (D) Alveolar capillary basal membrane damage.


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