A Trial of Ocrteotide in the Theatment of Severe Acute Pancreatitis

Kim, Nam Su; Lim, Cheol Su; Lee, Seung Ok; Kim, Joung Kwon; Lee, Soo Taek; Kim, Dae Ghon; Ahn, Deuk Soo

Abstract

BACKGROUND/AIMS: Somatostatin and its long acting analogue octreotide have been proposed for the treatment of patients with acute pancreatitis. But neither agents has been adequately assessed in patient with severe attacks, Retrospective study was carried out to assess the effect of octreotide in the treatment of patients with severe acute pancreatitis. The patients had been admitted between January, 1991 and August, 1996.
METHODS
Twenty two patients with severe acute pancreatitis were examined. We compared the differences in complication rate, mortality, mean hospital day between the conservative treatment group (nine patients) and the octreotide-treatment group (thirteen patients). For the octreotide treated group, octreotide 0.1 mg were injected subcutaneously every twelve haurs for average eleven days (11.38+7.43).
RESULTS
Complications occurred in 46% (6/13) of the octreotide-treatment group and 56% (5/9) of the control group. There was no significant difference in the incidence of complication (P=0.66). Mean hospital day of the octreotide-treatment group was 23+8,3 days and that of the control group was 15+10.8 days. However, these results were not statistically significant (P=0.09), There was one death due to sepsis in octreotide-treatment group.
CONCLUSIONS
Octreotide was not effective in the treatment of severe acute pancreatitis.