J Korean Acad Rehabil Med.  1998 Oct;22(5):1141-1144.

Serotonin Syndrome in Traumatic Brain Injury Patient: A case report

• Song Y
• Park I

Abstract

We report a 47-year old traumatic brain injury male patient who was treated for the rigidity and tremor with sinemet (carbidopa levodopa) and artane (trihexyphenidyl). He came to the emergency room ten days after the stopping of sinemet. Acute onset of increased obtunded, immobile, rigid, deep coma, and minimal response to a deep pain was presented. There was no evidence of the focal neurological signs. Over the next two days, he awoke with a normal mental status. His muscle tone become normal and he returned to home without residual medical problems or complications. We report a serotonin syndrome in a traumatic brain injury patient who was treated with sinemet and artane, which resulted in a dysregulation of serotonin activity.

Keyword

Serotonin syndrome; Traumatic brain injury; Sinemet

MeSH Terms

Brain Injuries*
Coma
Emergency Service, Hospital
Humans
Male
Middle Aged
Serotonin Syndrome*
Serotonin*
Tremor
Trihexyphenidyl
Serotonin
Trihexyphenidyl