J Korean Soc Radiol.  2013 May;68(5):397-405.

Relationship between Conventional Cardiovascular Disease Risk Assessment and Coronary Artery Calcification in Group Exposed to Inorganic Dusts

• Lee WJ
• Park SY

Abstract

PURPOSE
The purpose of this study is to determine the relationship between the coronary artery calcification (CAC) and the conventional cardiovascular disease risk assessment (CCDRA).
MATERIALS AND METHODS
This study included 101 subjects who were exposed to inorganic dusts and underwent CAC scoring by multidetector CT (MDCT), laboratory tests, and a standardized questionnaire for CCDRA, after being approved from the Institutional Review Board and providing informed consent. All subjects were divided as either non-calcified group (< 1, 55.4%) or calcified group (> or = 1, 44.6%) from total CAC, and evaluated by CCDRA, such as Framingham risk score (FRS) and National Cholesterol Education Program (NCEP). Receiver operating characteristic (ROC) area of FRS was generated for predicting CAC risk using SPSS program (ver. 19.0, Chicago, IL, USA).
RESULTS
Total CAC was significantly correlated with FRS (r = 0.283, p = 0.004). Crude odds ratio for CAC risk was 3.64 [95% confidence interval (CI) 1.39-9.52] in FRS > or = 20%, and 2.87 (95% CI 1.24-6.65) in the high risk group of NCEP. Subjects with pneumoconiosis showed higher values of CAC (p = 0.541) and FRS (p = 0.035) scores compared with subjects without pneumoconiosis. ROC area of FRS was 0.69 (95% CI 0.59-0.79) with a cutoff point of 13.5%.
CONCLUSION
CAC measured MDCT is significantly correlated with FRS than other CCDRA.

MeSH Terms

Cardiovascular Diseases
Chicago
Cholesterol
Coronary Vessels
Dust
Ethics Committees, Research
Informed Consent
Odds Ratio
Pneumoconiosis
Surveys and Questionnaires
Risk Assessment
ROC Curve
Vascular Calcification
Cholesterol
Dust

Figure

• 

  Fig. 1 Scatterplots show that correlation between FRS and TCS (A), between NCEP and TCS (B), between age and TCS (C), between age and FRS (D). TCS was significantly positively correlated with FRS (r = 0.283, p = 0.004) as well as NCEP (r = 0.247, p = 0.013). TCS and FRS significantly increased with age. Note.-FRS = Framingham risk score, NCEP = National Cholesterol Education Program, TCS = total calcium score

• 

  Fig. 2 Receiver operating characteristics curve illustrate that coronary artery calcification risk by Framingham risk score (FRS). Area under the curve (AUC) was 0.69 (95% CI, 0.59-0.79) with cutoff point of 13.5%. Note.-CI = confidence interval

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