J Korean Soc Plast Reconstr Surg.
2010 Mar;37(2):105-109.
Effect of Platelet-rich Plasma(PRP) on Regeneration of Rat Sciatic Nerve in a Silicone Chamber
- Affiliations
-
- 1Department of Plastic and Reconstructive Surgery, Research Institute of Plastic and Reconstructive Surgery, Seoul National University College of Medicine, Seoul, Korea.
- 2SMG-SUN Boramae Medical Center, Seoul, Korea. ejeong@kma.org
Abstract
- PURPOSE
The purpose of this study is to determine the effect of platelet-rich plasma(PRP) on rat sciatic nerve regeneration in a 10mm silicone chamber.
METHODS
A total of 6 inbred Lewis rats were used in this study. Bilateral sciatic neurectomy was performed on each rat. On one side, silicone chambers containing PRP solutions were implanted; on the contralateral side, the chambers without PRP were implanted as a control. In 12 weeks post-implantation, chambers were retrieved and both gastrocnemius muscles were excised. Nerves biopsy samples were examined under a light microscope after Masson trichrome staining.
RESULTS
Cross sections of the midpoints of PRP treated nerves were significantly larger and appeared more mature than those of controls.
CONCLUSION
Based on morphological evidence, PRP has a positive effect on neural regeneration, and it may therefore be useful for treating peripheral nerve injuries.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Effect of platelet-rich plasma on bone regeneration in ovariectomized osteoporotic rats
- Platelet-rich plasma, platelet derivatives, and their therapeutic importance in veterinary medicine
- The use of platelet-rich plasma in management of musculoskeletal pain: a narrative review
- The Effect of PRF and PRP for New Bone Formation of beta-TCP in Skull of White Rabbit
- Current clinical applications of platelet-rich plasma in various gynecological disorders: An appraisal of theory and practice
