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The Effect of Cryopreservation of Allograft Nerve on the Recovery of Motor Function

Choi SS, Park I, Hyun JK, Jung JU, Kim JP

PURPOSE: Peripheral nerve allograft can be an acceptable alternative, but it has not yet become clinically useful because of immune response to foreign tissue. With significant advances in the research...
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Comparison of Angiogenic Activities of Three Neuropeptides, Substance P, Secretoneurin, and Neuropeptide Y Using Myocardial Infarction

Lee J, Song M, Kim J, Park Y

BACKGROUND: The interplay between neurogenesis and angiogenesis is crucial during the development mediated by neuro-angiogenic morphogens. In particular, the angiogenic activity of neuropeptides and their role in tissue regeneration have...
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Sciatic nerve leachate of cattle causes neuronal differentiation of PC12 cells via ERK1/2 signaling pathway

Zhang Z, Liu Y, Zhu X, Wei L, Zhu J, Shi K, Wang G, Pan L

Previous studies have shown that the sciatic nerve has neurotrophic activity, and nerve regeneration, differentiation, and axon outgrowth can be modulated by different sciatic nerve preparations. However, numerous animals may...
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Schwann Cells Enhance Penetration of Regenerated Axons into Three-Dimensional Microchannels

Liu C, Kray J, Chan C

Nerve regeneration after injury requires proper axon alignment to bridge the lesion site and myelination to achieve functional recovery. Transplanted scaffolds with aligned channels, have been shown to induce axon...
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Free Functioning Muscle Transfer in Brachial Plexus Injury

Im JH, Park MS, Lee JY

The free functional muscle transfer (FFMT) is the surgical procedure aimed at reconstructing defective or deteriorated muscle function by grafting free muscles including blood vessels and nerves. Since the free...
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Effects of Canine and Murine Mesenchymal Stromal Cell Transplantation on Peripheral Nerve Regeneration

Sanchez DN, Bertanha M, Fernandes , de Lima Resende LA, Deffune E, Amorim RM

BACKGROUND AND OBJECTIVES: Maintaining a permissive microenvironment is essential for adequate nerve regeneration. Cell-based therapy has the potential based cell replacement and promotion of axonal growth. The adipose tissue derived...
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Spinal Cord Injury and Related Clinical Trials

Kim YH, Ha KY, Kim SI

Spinal cord injury (SCI) has been considered an incurable condition and it often causes devastating sequelae. In terms of the pathophysiology of SCI, reducing secondary damage is the key to...
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Vascular Endothelial Growth Factor Enhances Axonal Outgrowth in Organotypic Spinal Cord Slices via Vascular Endothelial Growth Factor Receptor 1 and 2

Park HW, Jeon HJ, Chang MS

Enhancing adult nerve regeneration is a potential therapeutic strategy for treating spinal cord injury. Vascular endothelial growth factor (VEGF) is a major contributor to angiogenesis, which can reduce the spinal...
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Neural Ablation and Regeneration in Pain Practice

Choi EJ, Choi YM, Jang EJ, Kim JY, Kim TK, Kim KH

A nerve block is an effective tool for diagnostic and therapeutic methods. If a diagnostic nerve block is successful for pain relief and the subsequent therapeutic nerve block is effective...
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Anatomical study of the nerve regeneration after selective neurectomy in the rabbit: clinical application for esthetic calf reduction

Shin KJ, Yoo JY, Lee JY, Gil YC, Kim JN, Koh KS, Song WC

The purposes of this study were therefore to characterize the degeneration and regeneration of nerves to the calf muscles after selective neurectomy, both macroscopically and microscopically, and to determine the...
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Regeneration of Recurrent Laryngeal Nerve using Polycaprolactone (PCL) Nerve Guide Conduit Coated with Conductive Materials

Choi JS, Kim H, An HY, Shim BS, Lim JY

BACKGROUND AND OBJECTIVES: Recurrent laryngeal nerve (RLN) damage commonly occurs from a thyroid surgery and causes communication impairment, aspiration and dysphagia. The purpose of this study is to develop a...
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Etifoxine for Pain Patients with Anxiety

Choi YM, Kim KH

Etifoxine (etafenoxine, Stresam(R)) is a non-benzodiazepine anxiolytic with an anticonvulsant effect. It was developed in the 1960s for anxiety disorders and is currently being studied for its ability to promote...
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Treatment of the Traumatic Neuroma

Roh YT, Park IJ

Formation of the traumatic neuroma results from abnormal nerve regeneration following a peripheral nerve injury. Numerous treatment options have been described. However, there is no one way that is completely...
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In Vivo Effects of Adipose-Derived Stem Cells in Inducing Neuronal Regeneration in Sprague-Dawley Rats Undergoing Nerve Defect Bridged with Polycaprolactone Nanotubes

Kim DY, Choi YS, Kim SE, Lee JH, Kim SM, Kim YJ, Rhie JW, Jun YJ

There have been many attempts for regeneration of peripheral nerve injury. In this study, we examined the in vivo effects of non-differentiated and neuronal differentiated adipose-derived stem cells (ADSCs) in...
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Aucubin Promotes Neurite Outgrowth in Neural Stem Cells and Axonal Regeneration in Sciatic Nerves

Kim YM, Sim UC, Shin Y, Kwon YK

Aucubin is an iridoid glycoside with a wide range of biological activities, including anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities. Recently, it has been shown that aucubin prevents neuronal...
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Application of Mesenchymal Stem Cells in Rhinologic Fields

Cho KS

Mesenchymal stem cells (MSCs) are adult stem cells which are present in a variety of adult tissues and reside in essentially all post-natal organs and tissues. MSCs represent an important...
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Effect of Macrophage Migration Inhibitory Factor on Corneal Sensitivity after Laser In Situ Keratomileusis in Rabbit

Hyon JY, Hose S, Gongora C, Sinha D, O'Brien T

PURPOSE: To investigate the effect of macrophage migration inhibitory factor (MIF) on corneal sensitivity after laser in situ keratomileusis (LASIK) surgery. METHODS: New Zealand white rabbits were used in this study....
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Controlled release of nerve growth factor from heparin-conjugated fibrin gel within the nerve growth factor-delivering implant

Lee JY, Kim SM, Kim MJ, Lee JH

OBJECTIVES: Although nerve growth factor (NGF) could promote the functional regeneration of an injured peripheral nerve, it is very difficult for NGF to sustain the therapeutic dose in the defect...
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Rat Peripheral Nerve Regeneration Using Nerve Guidance Channel by Porcine Small Intestinal Submucosa

Yi JS, Lee HJ, Lee HJ, Lee IW, Yang JH

OBJECTIVE: In order to develop a novel nerve guidance channel using porcine small intestinal submucosa (SIS) for nerve regeneration, we investigated the possibility of SIS, a tissue consisting of acellular...
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Effects of Human Mesenchymal Stem Cell Transplantation Combined with Polymer on Functional Recovery Following Spinal Cord Hemisection in Rats

Choi JS, Leem JW, Lee KH, Kim SS, Suh-Kim H, Jung SJ, Kim UJ, Lee BH

The spontaneous axon regeneration of damaged neurons is limited after spinal cord injury (SCI). Recently, mesenchymal stem cell (MSC) transplantation was proposed as a potential approach for enhancing nerve regeneration...
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