Relationship between Metabolic Syndrome and Bone Mineral Density in Middle-aged Women

Jeon, Su Kyung; Hong, Hye Ri; Yi, Kyong Wook; Park, Hyun Tae; Shin, Jung Ho; Lee, Nak Woo; Kim, Tak; Kim, Hai Joong; Hur, Jun Young; Kim, Sun Haeng

Abstract

OBJECTIVES
To determine the relationship between metabolic syndrome (MS) and bone mineral density (BMD) in middle-aged women.
METHODS
Three hundred eight premenopausal women were included in this study, including 268 women without MS and 40 women confirmed to have MS according to the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) criteria. Clinical markers including anthropometric parameters, the serum lipid profile, and glucose level were determined and analyzed with the BMD at the lumbar spine and femoral neck.
RESULTS
There was no significant difference in femoral neck or lumbar BMD between the controls and women with MS. In correlation tests, the body mass index (BMI) showed a significant association with the femoral (r = 0.209, P < 0.001) and lumbar BMD (r = 0.176, P = 0.002). In addition, the waist circumference (WC) was also significantly correlated with the femoral (r = 0.142, P = 0.012) and lumbar BMD (r = 0.113, P = 0.048).
CONCLUSION
The BMI and WC showed a significant positive association with the femoral and lumbar spine BMD in premenopausal women. Further studies with a large population will be needed to elucidate the combined effect of MS on BMD in middle-aged women.