Tuberc Respir Dis.  2015 Oct;78(4):416-418. 10.4046/trd.2015.78.4.416.

Nontuberculous Mycobacterial Lung Disease Caused by Mycobacterium shinjukuense: The First Reported Case in Korea

• Moon SM
• Kim SY
• Chung MJ
• Lee SH
• Shin SJ
• Koh WJ

• KMID: 2320718
• DOI: http://doi.org/10.4046/trd.2015.78.4.416

Abstract

Mycobacterium shinjukuense is a novel species of nontuberculous mycobacteria (NTM) that was first reported in Japan in 2011. It is a slow-growing NTM pathogen that can cause chronic pulmonary infections. There are only a few reported cases of M. shinjukuense infections, all of which are from Japan. We reported a case of chronic lung disease caused by M. shinjukuense. The organism was identified by 16S rRNA, rpoB, and hsp65 gene sequencing. To the best of our knowledge, this was the first confirmed case of lung disease caused by M. shinjukuense outside of Japan.

Keyword

Bronchiectasis; Mycobacterium; Nontuberculous Mycobacteria

MeSH Terms

Bronchiectasis
Japan
Korea*
Lung Diseases*
Lung*
Mycobacterium*
Nontuberculous Mycobacteria

Figure

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  Figure 1 A 57-year-old female with a chronic cough productive with sputum. Axial computed tomography (CT) imaging shows several nodules, micro-nodules, and bronchiectasis with lung atelectasis in the right middle lobe. It also reveals bronchiectasis with lung atelectasis in the lingular division of the left upper lobe. These are typical CT findings of the nodular bronchiectatic form commonly seen in nontuberculous mycobacterial disease.

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  Figure 2 The phylogenetic position of isolated SMC-shi-001 strain from the patient in this report and other species belonging to the slow growing mycobacteria, based on the rpoB sequence. This tree is constructed using the neighbor-joining method. The percentages indicated at nodes represent bootstrap levels supported by 1,000 re-sampled datasets. Scale bars indicate evolutionary distance in base substitutions per site. M., Mycobacterium.

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