Tuberc Respir Dis.  2012 Feb;72(2):207-211.

A Case of Hemolytic Uremic Syndrome in a Lung Cancer Patient Treated with Gemcitabine

• Park YJ
• Yang KS
• Jung HS
• Nam HC
• Jung SH
• Kim BG
• Kim KY
• Kim JH
• Kim YO
• Yun YS

Abstract

Hemolytic uremic syndrome (HUS) is a rare disorder characterized by the triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. HUS arises from a wide spectrum of conditions, and chemotherapeutic agents have been reported to be associated with HUS, including Mitomycin, Cisplatin, Bleomycin, and Gemcitabine. A 76-year-old man treated with Gemcitabine due to non-small cell lung cancer developed clinical and laboratory findings compatible with HUS. Gemcitabine was ceased and hemodialysis and plasma exchange were utilized and he recovered. A high level of suspicion for HUS is necessary when cancer patients are treated with Gemcitabine, and prompt recognition and treatment are also essential.

Keyword

Hemolytic-Uremic Syndrome; Gemcitabine; Lung Neoplasms

MeSH Terms

Acute Kidney Injury
Aged
Anemia, Hemolytic
Bleomycin
Carcinoma, Non-Small-Cell Lung
Cisplatin
Deoxycytidine
Hemolytic-Uremic Syndrome
Humans
Lung
Lung Neoplasms
Mitomycin
Plasma Exchange
Renal Dialysis
Thrombocytopenia
Bleomycin
Cisplatin
Deoxycytidine
Mitomycin

Figure

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  Figure 1 Peripheral blood smear showed schistocytes (× 400).

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  Figure 2 Chest X-ray showed a right pleural effusion with atelectasis in RLL and Chemopoprt insert state via left internal jugular vein. RLL: right lower lobe.

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