Tuberc Respir Dis.  2010 Nov;69(5):375-380.

Lymphoid Interstitial Pneumonia Associated with Primary Sjogren's Syndrome: A Case Report

• Mo SI
• Lee HG
• Cho AR
• Chung HK
• Lee HS
• Choi JS
• Seo KH
• Nah SS
• Kim YH
• Na JO

Abstract

Lymphoid interstitial pneumonia (LIP) is a rare benign lymphoproliferative interstitial lung disease. LIP has been associated with autoimmune disorders, HIV, viral infections, and so on. Once underlying systemic diseases have been excluded, a diagnosis of idiopathic LIP can be made. Although 6 cases of pathologically confirmed LIP have occurred in Korea, thus far none has been associated with primary Sjogren's syndrome. A 44-year-old man was admitted to hospital due to a dry cough and dypsnea on exertion that had been ongoing for 2 months. A chest radiography showed multiple and variable-sized cystic lesions, on both lungs and both interstitial infiltration and consolidation in both lower lung fields. Tests for autoantibody showed positive results of anti-nuclear antibody and anti-Ro/La antibody. The patient underwent a video assisted thoracoscopic surgery biopsy and pathologically confirmed LIP. We report the first known case of LIP-associated with primary Sjogren's syndrome in Korea.

Keyword

Sjogren's Syndrome; Lung Diseases, Interstitial; Lymphoid Interstitial Pneumonia

MeSH Terms

Adult
Biopsy
Cough
HIV
Humans
Korea
Lip
Lung
Lung Diseases, Interstitial
Sjogren's Syndrome
Thoracic Surgery, Video-Assisted
Thorax
Lung Diseases, Interstitial

Figure

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  Figure 1 Chest X-ray on admission shows 5-cm sized cystic lesion at right hilar area and irregular-shaped consolidation with interstitial infiltration at both lower lung field.

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  Figure 2 High resolution computed tomography of chest on admission shows multiple cystic lesions, ground glass opacity, and consolidation with traction bronchiectasis at both lungs.

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  Figure 3 Histopathologic finding of the resected lung tissue. Right lower lobe revealed lymphocytes and plasma cells infiltration in the interstitium and alveolar septum. Also, there was noncaseating granuloma and follicular bronchiolitis (A, H&E stain, ×40; B, H&E stain, ×200).

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