Tuberc Respir Dis.  2009 Dec;67(6):556-559.

A Case of Acute Eosinophilic Pneumonia Associated with Intramuscular Administration of Progesterone Following In Vitro Fertilization

• Park SK
• Choi BH
• Chon SY
• Kim YJ
• Kyung SY
• Lee SP
• Jeong SH
• Park JW

Abstract

Acute eosinophilic pneumonia (AEP) is characterized by idiopathic acute febrile illness, diffuse pulmonary infiltration, severe hypoxemia, and pulmonary eosinophilia. We report a case of AEP associated with intramuscular administration of progesterone as luteal phase support after in vitro fertilization. A 33-year-old woman presented to our emergency room with tachypnea and hypoxemia, complaining of fever and cough for 4 days, and dyspnea for 2 days. The symptoms began 9 days after the first injection of progesterone. Chest radiograph showed bilateral infiltrates, located predominantly in the periphery of the lungs, with blunting of the costophrenic angle. Symptoms and chest radiograph dramatically improved after corticosteroid therapy and shifting the progesterone from an intramuscular form of administration to a vaginal form of administration.

Keyword

Pulmonary Eosinophilia; Progesterone; Eosinophilia

MeSH Terms

Adult
Anoxia
Cough
Dyspnea
Emergencies
Eosinophilia
Eosinophils
Female
Fertilization in Vitro
Fever
Humans
Lung
Luteal Phase
Progesterone
Pulmonary Eosinophilia
Tachypnea
Thorax
Progesterone

Figure

• 

  Figure 1 (A) Chest radiograph on admission (hospital day 1) shows bilateral infiltrates, predominantly located in the periphery of the lungs, with blunting of costophrenic angle. (B) Chest radiograph shows dramatic improvement of previous bilateral infiltrates, disappeared blunting of costophrenic angle 3 days after systemic corticosteroid therapy and shifting the progesterone from an intramuscular form to vaginal form.

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