Tuberc Respir Dis.  2005 May;58(5):480-489.

Relationship between Expression of XIAP Protein in Operable Non- small Cell Lung Carcinomas and Apoptosis Index and Postoperative Prognosis

• Kim SH
• Lee CH
• Sol MY
• Song JM
• Lee JH
• Lee MK
• Kim JM

Abstract

BACKGROUND: Dysregulation of apoptosis plays an important role in carcinogenesis, tumor progression, and resistance to chemotherapy. X-linked inhibitor of apoptosis (XIAP) is considered to be the most potent caspase inhibitor of all known IAP (inhibitor of apoptosis) family members. This study was designed to assess the pattern of expression and the prognostic value of XIAP in radically resected non-small cell lung carcinoma (NSCLC) patients. METHOD: The expression of XIAP and its relationship with clinicopathologic parameters (patient age, TNM stage, TNM-pT, TNM-pN, histologic type, VEGF expression, microvessel density, PCNA index) and overall survival were analysed with formalin-fixed, paraffin-embedded blocks from eighty cases of NSCLC. In addition, the apoptotic index (AI) was also assessed.
RESULTS
In a regard to histologic type, squamous cell carcinoma (SCC) showed XIAP expression in 91.3%(42/46) and adenocarcinoma (AC) in 61.8%(21/34). The difference was significant(p=0.001). There was no correlation between XIAP expression and other parameters. In the group of AC, XIAP expression showed the signifcant correlation with older age group > or = 58 years and VEGF expression(p=0.028, p=0.014, respectively). The AI in the group with or without XIAP expression were 2.5+/-4.9% and 18.5+/-28.9%, respectively(p=0.001). Both groups just aforementioned showed no significant difference in median survival time (42.5 months, 29.8 months, respectively).
CONCLUSION
This study suggests that the XIAP expression in NSCLCs could have relation to inhibition of apoptosis, and show differential expression according to histologic type. However, its prognostic role during the progression of NSCLC needs to be further defined.

Keyword

Carcinoma; Non-small cell lung; Inhibitor-of-apoptosis protein; Apoptosis

MeSH Terms

Adenocarcinoma
Apoptosis*
Carcinogenesis
Carcinoma, Squamous Cell
Drug Therapy
Humans
Inhibitor of Apoptosis Proteins
Lung
Microvessels
Prognosis*
Proliferating Cell Nuclear Antigen
Small Cell Lung Carcinoma*
Vascular Endothelial Growth Factor A
X-Linked Inhibitor of Apoptosis Protein*
Inhibitor of Apoptosis Proteins
Proliferating Cell Nuclear Antigen
Vascular Endothelial Growth Factor A
X-Linked Inhibitor of Apoptosis Protein