- Is Whole Exome Sequencing Clinically Practical in the Management of Pediatric Crohn's Disease?
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Oh SH, Baek J, Kim KM, Lee EJ, Jung Y, Lee YJ, Jin HS, Ye BD, Yang SK, Lee JK, Seo EJ, Lim HT, Lee I, Song K
- KMID: 2377935
- Gut Liver.
- 2015 Nov;9(6):767-775.
- doi: 10.5009/gnl15176
BACKGROUND/AIMS: The aim of this study was to identify the profile of rare variants associated with Crohn's disease (CD) using whole exome sequencing (WES) analysis of Korean children with CD... -
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- Anthocyanins From the Fruit of Vitis coignetiae Pulliat Potentiate the Cisplatin Activity by Inhibiting PI3K/Akt Signaling Pathways in Human Gastric Cancer Cells
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Lu JN, Lee WS, Nagappan A, Chang SH, Choi YH, Kim HJ, Kim GS, Ryu CH, Shin SC, Jung JM, Hong SC
- KMID: 2171317
- J Cancer Prev.
- 2015 Mar;20(1):50-56.
- doi: 10.15430/JCP.2015.20.1.50
BACKGROUND: Cisplatin (cis-diaminedichloroplatinum, CDDP) is a widely used chemotherapeutic agent for the treatment of many cancers. However, initial resistance to CDDP is a serious problem in treating these cancers. Vitis... -
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- Characterization of H460R, a Radioresistant Human Lung Cancer Cell Line, and Involvement of Syntrophin Beta 2 (SNTB2) in Radioresistance
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Im CN, Kim BM, Moon EY, Hong DW, Park JW, Hong SH
- KMID: 2166509
- Genomics Inform.
- 2013 Dec;11(4):245-253.
- doi: 10.5808/GI.2013.11.4.245
A radioresistant cell line was established by fractionated ionizing radiation (IR) and assessed by a clonogenic assay, flow cytometry, and Western blot analysis, as well as zymography and a wound... -
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- Induction of ER Stress-Mediated Apoptosis by alpha-Lipoic Acid in A549 Cell Lines
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Kim JI, Cho SR, Lee CM, Park ES, Kim KN, Kim HC, Lee HY
- KMID: 2063120
- Korean J Thorac Cardiovasc Surg.
- 2012 Feb;45(1):1-10.
BACKGROUND: alpha-Lipoic acid (alpha-LA) has been studied as an anticancer agent as well as a therapeutic agent for diabetes and obesity. We performed this study to evaluate the anticancer effects... -
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- Expression of X-linked Inhibitor of Apoptosis Protein in Neoplastic Thyroid Disorder
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Yim JH, Yoon JH, Kim SA, Kim WG, Jeon MJ, Han JM, Sung TY, Kim TY, Kim WB, Hong SJ, Shong YK, Gong G
- KMID: 1779393
- J Korean Med Sci.
- 2011 Sep;26(9):1191-1195.
- doi: 10.3346/jkms.2011.26.9.1191
X-linked inhibitor of apoptosis protein (XIAP) is associated with tumor genesis, growth, progression and metastasis, and acts by blocking caspase-mediated apoptosis. In the present study, we sought to evaluate the... -
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- Inhibitors of Apoptosis Proteins Expression and Their Prognostic Significance in Colorectal Carcinoma
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Lee KH, Lee S, Lee HM, Back SC, Cho SB, Lee JH
- KMID: 2277504
- Korean J Pathol.
- 2011 Aug;45(4):397-405.
BACKGROUND: The expression of the inhibitor of apoptosis proteins (IAPs) family has not been fully investigated in colorectal carcinomas. This study investigated IAP expression in colorectal carcinomas and assessed their... -
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- Chestnut extract induces apoptosis in AGS human gastric cancer cells
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Lee HS, Kim EJ, Kim SH
- KMID: 2313516
- Nutr Res Pract.
- 2011 Jun;5(3):185-191.
In Korea, chestnut production is increasing each year, but consumption is far below production. We investigated the effect of chestnut extracts on antioxidant activity and anticancer effects. Ethanol extracts of... -
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- Apoptotic effect of NV-196, an isofl avone derivative, in epithelial ovarian cancer cells
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Suh DS, Joo JK, Kim SC, Lee DH, Yi WH, Yoon MS, Kim KH
- KMID: 2037496
- Korean J Obstet Gynecol.
- 2011 Feb;54(2):86-92.
- doi: 10.5468/KJOG.2011.54.2.86
OBJECTIVE: The objectives of this study were to determine the efficacy of NV-196, a synthetic isoflavone derivative, as a chemosensitizer in chemoresistant CP70 and R182 epithelial ovarian cancer (EOC) cells... -
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- The effect of combined treatment with cisplatin and histone deacetylase inhibitors on HeLa cells
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Jin KL, Park JY, Noh EJ, Hoe KL, Lee JH, Kim JH, Nam JH
- KMID: 2173551
- J Gynecol Oncol.
- 2010 Dec;21(4):262-268.
- doi: 10.3802/jgo.2010.21.4.262
OBJECTIVE: To investigate the combined effects of cisplatin and the histone deacetylase (HDAC) inhibitors suberoylanilide hydroxamic acid (SAHA) or sirtinol on HeLa cells and assess the mechanism underlying HDAC inhibitor-cisplatin... -
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- Overexpression of X-linked Inhibitor of Apoptosis Protein (XIAP) is an Independent Unfavorable Prognostic Factor in Childhood de Novo Acute Myeloid Leukemia
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Sung KW, Choi J, Hwang YK, Lee SJ, Kim HJ, Kim JY, Cho EJ, Yoo KH, Koo HH
- KMID: 1779191
- J Korean Med Sci.
- 2009 Aug;24(4):605-613.
- doi: 10.3346/jkms.2009.24.4.605
The overexpression of X-linked inhibitor of apoptosis protein (XIAP), a member of IAP family protein, is intuitively expected to be associated with unfavorable clinical features in malignancies; however, there have... -
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- Relationship between Expression of XIAP Protein in Operable Non- small Cell Lung Carcinomas and Apoptosis Index and Postoperative Prognosis
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Kim SH, Lee CH, Sol MY, Song JM, Lee JH, Lee MK, Kim JM
- KMID: 2318616
- Tuberc Respir Dis.
- 2005 May;58(5):480-489.
BACKGROUND: Dysregulation of apoptosis plays an important role in carcinogenesis, tumor progression, and resistance to chemotherapy. X-linked inhibitor of apoptosis (XIAP) is considered to be the most potent caspase inhibitor... -
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