Tuberc Respir Dis.  2000 Mar;48(3):324-330.

Immunohistochemical Staining of Insulin-like Growth Factor-1 in Human Lung Cancer cells of NSCLC and SCLC

• Park JH
• Kang MJ
• Lee HB
• Lee YC
• Rhee YK

Abstract

OBJECTIVE
Lung cancer arises after a series of morphological changes, which take several years to progress from normal epithelium to invasive cancer. Multiple molecular changes and growth factors factor production have been documented in lung cancers, both small cell and non-small cell types. Insulin-like growth factors(IGFs) are important mitogenic and anabolic peptides, both in vivo and in vitro, and are thought to be significant autocrine-paracrine factors involved in normal and malignant cell proliferation. In this study, we have investigated (delete) the degree of expression of IGF-1 on the immunohistochemical staining in human non-small cell lung cancer(NSCLC) cells and small cell lung cancer (SCLC) cells were investigated.
METHODS
Immunohistochemical staining for IGF-1 was performed in 15 cases of small cell carcinoma, 15 cases of squamous cell carcinoma, 15 cases of adenocarcinoma, and 12 cases of bronchoalveolar carcinoma.
RESULTS
The NSCLC cells showed significantly increased expression The expression of IGF-1 on the immunohistochemical staining significantly increased in NSCLC cells than in SCLC cells.
CONCLUSION
These results suggest that IGF-1 are expressed the expression of IGF-1 in human lung cancer cells(.), and the (The) immunohistochemical staining of IGF-1 in lung cancer cell lines may help in differentiation of may assist in the differentiation of NSCLC and SCLC.

Keyword

Insulin-like growth factor-1(IGF-1); Small cell lung cancer(SCLC) Non-small cell lung cancer(NSCLC); Immunohistochemical staining

MeSH Terms

Adenocarcinoma
Carcinoma, Small Cell
Carcinoma, Squamous Cell
Cell Line
Cell Proliferation
Epithelium
Humans*
Insulin-Like Growth Factor I
Intercellular Signaling Peptides and Proteins
Lung Neoplasms*
Lung*
Peptides
Small Cell Lung Carcinoma
Insulin-Like Growth Factor I
Intercellular Signaling Peptides and Proteins
Peptides