Tuberc Respir Dis.  1997 Oct;44(5):1019-1029.

Resting Energy Expenditure in Patients with Lung Cancer

Affiliations
  • 1Department of Internal Medicine, College of Medicine, Yeungnam University, Taegu, Korea.

Abstract

BACKGROUND: Elevation of resting energy expenditure(REE) in patients with lung cancer has been described in earlier studies and may contribute to cancer cachexia, but limited information is available regarding the prevalence and determinants of the increased REE. The aim of this study was to assess the prevalence and contributing factors of a hypermetabolic state in newly detected patients with lung cancer and to assess the energy balance in order to improve our knowledge about weight loss in patients with lung cancer.
METHODS
Thirty one consecutive, newly detected patients with lung cancer and 20 control patients with benign lung diseases were included in this study. Resting energy expenditure(REE) was measured by indirect calorimetry using ventilated hood system and predicted REE was calculated by the Harris-Benedict formular.
RESULTS
The energy balance in newly detected lung cancer patients was disturbed in a high proportion of patients, and hypermetabolic state occurred in 61% of the patients. Tumor volume, cancer type, location, stage, the presence of atelectasis or infiltration, pulmonary fuction, or smoking behavior were not associated with increase in REE. But patients with distant metastasis had significantly higher REE comparing with patients without metastasis. Thirty nine percents of the patients with lung cancer had substantial loss of more than 10% of their pre-illness weight. Weight losing patients with lung cancer were not accompanied by an increase in REE.
CONCLUSION
We concluded that the REE was elevated in a higher proportion of patients with lung cancer and distant metastasis was found to be contributing factor to the elevated REF.

Keyword

Lung cancer; Resting energy expenditure

MeSH Terms

Cachexia
Calorimetry, Indirect
Energy Metabolism*
Humans
Lung Diseases
Lung Neoplasms*
Lung*
Neoplasm Metastasis
Prevalence
Pulmonary Atelectasis
Smoke
Smoking
Tumor Burden
Weight Loss
Smoke
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