Psychiatry Investig.
2015 Apr;12(2):227-234. 10.4306/pi.2015.12.2.227.
Increased Cognition Connectivity Network in Major Depression Disorder: A fMRI Study
- Affiliations
-
- 1Division of Mood Disorders, Psychiatry Department, Shanghai Mental Health Center, Shanghai Jiaotong University, Shanghai, China. pdhsh@126.com, hyyyyb@gmail.com
- 2Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, China.
- 3Department of Medical Imaging, Shanghai Fifth People's Hospital, Shanghai, China.
- 4Huashan Hospital, Fudan University, Shanghai, China.
- KMID: 2316433
- DOI: http://doi.org/10.4306/pi.2015.12.2.227
Abstract
OBJECTIVE
Evidence of the brain network involved in cognitive dysfunction has been inconsistent for major depressive disorder (MDD), especially during early stage of MDD. This study seeks to examine abnormal cognition connectivity network (CCN) in MDD within the whole brain.
METHODS
Sixteen patients with MDD and 16 health controls were scanned during resting-state using 3.0 T functional magnetic resonance imaging (fMRI). All patients were first episode without any history of antidepressant treatment. Both the left and right dorsolateral prefrontal cortex (DLPFC) were used as individual seeds to identify CCN by the seed-target correlation analysis. Two sample t test was used to calculate between-group differences in CCN using fisher z-transformed correlation maps.
RESULTS
The CCN was constructed by bilateral seed DLPFC in two groups separately. Depressed subjects exhibited significantly increased functional connectivity (FC) by left DLPFC in one cluster, overlapping middle frontal gyrus, BA7, BA43, precuneus, BA6, BA40, superior temporal gyrus, BA22, inferior parietal lobule, precentral gyrus, BA4 and cingulate gyrus in left cerebrum. Health controls did not show any cluster with significantly greater FC compared to depressed subjects in left DLPFC network. There was no significant difference of FC in right DLPFC network between depressed subjects and the health controls.
CONCLUSION
There are differences in CCN during early stage of MDD, as identified by increased FCs among part of frontal gyrus, parietal cortex, cingulate cortex, and BA43, BA22, BA4 with left DLPFC. These brain areas might be involved in the underlying mechanisms of cognitive dysfunction in MDD.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Abnormal Dynamic Functional Connectivity of the Left Rostral Hippocampus in Predicting Antidepressant Efficacy in Major Depressive Disorder
- Alteration in the Local and Global Functional Connectivity of Resting State Networks in Parkinson's Disease
- The Feasibility for Whole-Night Sleep Brain Network Research Using Synchronous EEG-fMRI
- Recent Advances on Resting State Functional Abnormalities of the Default Mode Network in Social Anxiety Disorder
- Altered Functional Brain Networks in Patients with Traumatic Anosmia: Resting-State Functional MRI Based on Graph Theoretical Analysis
