Psychiatry Investig.  2015 Jan;12(1):142-145. 10.4306/pi.2015.12.1.142.

Bupropion for Interferon-Alpha-Induced Depression in Patients with Hepatitis C Viral Infection: An Open-Label Study

• Chen WC
• Lai HC
• Su WP
• Palani M
• Su KP

• KMID: 2316400
• DOI: http://doi.org/10.4306/pi.2015.12.1.142

Abstract

Interferon (IFN)-alpha therapy for chronic hepatitis C virus (HCV) infection is frequently associated with major depressive episodes. Bupropion, a commonly used antidepressant agent, has recently found to have strong anti-inflammatory effects in animal models. Despite of the theoretical relevancy, the antidepressant effect of bupropion in IFN-alpha-induced depression has never been studied. Ten HCV patients with IFN-alpha-induced depression were recruited to receive 8-week bupropion treatment and were assessed every 2 weeks for depressive symptoms by the Hamilton rating scale for depression (HAMD) and somatic symptoms by the Neurotoxicity Rating Scale (NRS). Four of the 10 patients met the criteria for remission (total HAMD scores< or =7), and 5 patients met the criteria for response (at least 50% reduction in total HAMD scores). In addition, 5 patients had 50% decreases in NRS for neuropsychiatric symptoms. This preliminary open-label study suggests that bupropion is effective in treating IFN-alpha-induced depressive and somatic symptoms.

Keyword

Interferon-induced depression; Bupropion; Antidepressant; Hepatitis C viral infection

MeSH Terms

Bupropion*
Depression*
Hepatitis C*
Hepatitis C, Chronic
Humans
Interferons
Models, Animal
Bupropion
Interferons