- Interactive Effects of Serum Leptin Levels and Physical Comorbidity on the Pharmacotherapeutic Response of Depressive Disorders
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Choi W, Kim JW, Kang HJ, Kim HK, Kang HC, Lee JY, Kim SW, Stewart R, Kim JM
- KMID: 2536476
- Clin Psychopharmacol Neurosci.
- 2022 Nov;20(4):662-674.
- doi: 10.9758/cpn.2022.20.4.662
Objective: To investigate individual and interactive associations of baseline serum leptin levels and physical comorbidity with short- and long-term treatment outcomes in outpatients with depressive disorders who received stepwise antidepressant... -
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- “Drugs of Abuse” as a “New Antidepressant”: - A Review on Pharmacological Mechanisms, Antidepressant Effects, and Abuse Potential
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An Y, Park SY, Kang UG
- KMID: 2536663
- J Korean Neuropsychiatr Assoc.
- 2022 Nov;61(4):243-253.
- doi: 10.4306/jknpa.2022.61.4.243
Drugs once classified as ‘substances of abuse’ are now drawing attention in the field of psychiatry as ‘new antidepressants’ for the management of treatment-resistant depression (TRD). Intranasal esketamine was approved... -
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- Safety and Effectiveness of Desvenlafaxine in Korean Patients with Major Depressive Disorder: A 6-month Postmarketing Surveillance Study
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Roh S, Lee KS, Choi S, Kim JM
- KMID: 2532820
- Clin Psychopharmacol Neurosci.
- 2022 Aug;20(3):548-559.
- doi: 10.9758/cpn.2022.20.3.548
Objective: Although the safety and efficacy of desvenlafaxine have been demonstrated, long-term evidence in Asians is lacking. We examined the safety and effectiveness of desvenlafaxine for up to 6 months... -
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- Abnormal Dynamic Functional Connectivity of the Left Rostral Hippocampus in Predicting Antidepressant Efficacy in Major Depressive Disorder
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Xue SW, Kuai C, Xiao Y, Zhao L, Lan Z
- KMID: 2532055
- Psychiatry Investig.
- 2022 Jul;19(7):562-569.
- doi: 10.30773/pi.2021.0386
Objective Some pharmacological treatments are ineffective in parts of patients with major depressive disorder (MDD), hence this needs prediction of effective treatment responses. The study aims to examine the relationship... -
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- Vortioxetine Induced Hypomania: A Case Presentation and Review of the Literature
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Tunc EB, Tunc S
- KMID: 2530474
- Clin Psychopharmacol Neurosci.
- 2022 May;20(2):394-397.
- doi: 10.9758/cpn.2022.20.2.394
Antidepressant-induced hypomania/mania is a complex issue that can be seen in mood disorders but is not clarified. There are case reports in the literature regarding vortioxetine-induced mania and hypomania;... -
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- Associations of Serum Serotonin Levels with 12-week and 12-month Remission in Patients with Depressive Disorders
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Choi W, Kang HJ, Kim JW, Kim HK, Kang HC, Lee JY, Kim SW, Stewart R, Kim JM
- KMID: 2530460
- Clin Psychopharmacol Neurosci.
- 2022 May;20(2):248-258.
- doi: 10.9758/cpn.2022.20.2.248
Objective: To investigate associations between baseline serum serotonin levels and short- and long-term treatment outcomes in outpatients with depressive disorders in a naturalistic one-year prospective study design. Methods: Patients were recruited... -
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- A Study of Dry Mouth and Gastrointestinal Disorders in Patients Taking Antidepressant
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Heo YJ, Yang CM, Lee HJ, Lee SY, Jang SH
- KMID: 2538379
- Mood Emot.
- 2022 Mar;20(1):15-22.
- doi: 10.35986/me.2022.20.1.15
Background: The purpose of this study was to identify the characteristics of dry mouth and gastrointestinal (GI) disorders in antidepressant patients. Methods: The study included 103 antidepressant-taking patients. Antidepressants were classified... -
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- Additional Reduction of Residual Symptoms with Aripiprazole Augmentation in the Patients with Partially Remitted Major Depressive Disorder
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Shin C, Pae CU, Kwak KP, Jeon SW, Jeong HG, Kim JW, Lee YJ, Patkar AA, Han C
- KMID: 2516176
- Clin Psychopharmacol Neurosci.
- 2021 May;19(2):243-253.
- doi: 10.9758/cpn.2021.19.2.243
Objective: Many patients with major depressive disorder (MDD) suffer from residual symptoms without achieving remission. However, pharmacologic options for residual symptoms of MDD have been limited. This study aimed to... -
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- The Usefulness and Clinical Characteristics of Antidepressant Use for Stroke Patients with Rehabilitation Program: An Exploratory Analysis
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Lee KH, Park GY, Bahk WM, Lee SJ, Pae CU
- KMID: 2505677
- Clin Psychopharmacol Neurosci.
- 2020 Aug;18(3):445-449.
- doi: 10.9758/cpn.2020.18.3.445
Objective: There has been a lack of data regarding the usefulness and clinical characteristic between patients-treated with and without antidepressants (Pw/Pwo ADs). Methods: One hundred and eighty inpatients were recruited and... -
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- Ketamine in Major Depressive Disorder: Mechanisms and Future Perspectives
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Shin C, Kim YK
- KMID: 2501496
- Psychiatry Investig.
- 2020 Mar;17(3):181-192.
- doi: 10.30773/pi.2019.0236
Major depressive disorder (MDD) is a serious psychiatric illness that causes functional impairment in many people. While monoaminergic antidepressants have been used to effectively treat MDD, these antidepressants have limitations... -
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- Personalized Psychiatry and Depression: The Role of Sociodemographic and Clinical Variables
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Perna G, Alciati A, Daccò S, Grassi M, Caldirola
- KMID: 2501497
- Psychiatry Investig.
- 2020 Mar;17(3):193-206.
- doi: 10.30773/pi.2019.0289
Despite several pharmacological options, the clinical outcomes of major depressive disorder (MDD) are often unsatisfactory. Personalized psychiatry attempts to tailor therapeutic interventions according to each patient’s unique profile and characteristics.... -
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- Genetics of Treatment Outcomes in Major Depressive Disorder: Present and Future
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Fabbri C, Serretti A
- KMID: 2502121
- Clin Psychopharmacol Neurosci.
- 2020 Feb;18(1):1-9.
- doi: 10.9758/cpn.2020.18.1.1
Pharmacogenetic testing is a useful and increasingly widespread tool to assist in antidepressant prescription. More than ten antidepressants (including tricyclics, selective serotonin reuptake inhibitors and venlafaxine) have already genetic biomarkers... -
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- C-Reactive Protein Gene Variants in Depressive Symptoms & Antidepressants Efficacy
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Li X, Sun N, Yang C, Liu Z, Li X, Zhang K
- KMID: 2467299
- Psychiatry Investig.
- 2019 Dec;16(12):940-947.
- doi: 10.30773/pi.2019.0117
OBJECTIVE: Although the pathogenesis of depression remains unclear, C-reactive protein (CRP) levels are commonly elevated in depressed patients. Thus, CRP single-nucleotide polymorphisms (SNPs) that influence CRP levels may be associated... -
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- The Efficacy of Miniaturized Repetitive Transcranial Magnetic Stimulation in Patients with Depression
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Lee S, Jang KI, Yoon S, Chae JH
- KMID: 2457404
- Clin Psychopharmacol Neurosci.
- 2019 Aug;17(3):409-414.
- doi: 10.9758/cpn.2019.17.3.409
OBJECTIVE: The present study aimed to evaluate the efficacy of repetitive transcranial magnetic stimulation (rTMS) at a high frequency using a miniaturized device compared to standard rTMS and sham rTMS... -
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- Is Advancing Circadian Rhythm the Mechanism of Antidepressants?
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Lee HJ
- KMID: 2454716
- Psychiatry Investig.
- 2019 Jul;16(7):479-483.
- doi: 10.30773/pi.2019.06.20
Antidepressants usually require 2–8 weeks after drug administration to obtain a clinical response. In contrast, three fast-acting antidepressant treatments (sleep deprivation, electroconvulsive therapy, and ketamine) significantly reduced depressive symptoms within... -
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- Clinical Characteristics and Psychotropic Drug Prescription Patterns of Bipolar Disorder Patients with a History of Suicidal Attempts: Findings from the REAP-BD, Korea
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Park SC, Kim K, Jang OJ, Kim SG, Lee JG, Park JH, Choi J, Lee DW, Lin SK, Tan CH, Shinfuku N, Park YC
- KMID: 2451941
- Psychiatry Investig.
- 2019 Jun;16(6):459-463.
- doi: 10.30773/pi.2019.03.10
Our study aimed to analyze the clinical characteristics and psychotropic prescription patterns of a history of suicide attempts in South Koreans with bipolar disorder (BD), by using only Korean data... -
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- Examining Patterns of Polypharmacy in Bipolar Disorder: Findings from the REAP-BD, Korea
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Kim K, Yang H, Na E, Lee H, Jang OJ, Yoon HJ, Oh HS, Ham BJ, Park SC, Lin SK, Tan CH, Shinfuku N, Park YC
- KMID: 2449912
- Psychiatry Investig.
- 2019 May;16(5):397-402.
- doi: 10.30773/pi.2019.02.26.4
Based on Korean data from the Research on Asian Psychotropic Prescription Pattern for Bipolar Disorder, this study tried to present prescription patterns in biopolar disorder (BD) and its associated clinical... -
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- Extracellular Vesicles Derived from Lactobacillus plantarum Increase BDNF Expression in Cultured Hippocampal Neurons and Produce Antidepressant-like Effects in Mice
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Choi J, Kim YK, Han PL
- KMID: 2450211
- Exp Neurobiol.
- 2019 Apr;28(2):158-171.
- doi: 10.5607/en.2019.28.2.158
Gut microbiota play a role in regulating mental disorders, but the mechanism by which gut microbiota regulate brain function remains unclear. Gram negative and positive gut bacteria release membrane-derived extracellular... -
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- Investigation of the Proarrhythmic Effects of Antidepressants according to QT Interval, QT Dispersion and T Wave Peak-to-End Interval in the Clinical Setting
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Okayasu H, Ozeki Y, Fujii K, Takano Y, Shinozaki , Ohrui M, Shimoda K
- KMID: 2440628
- Psychiatry Investig.
- 2019 Feb;16(2):159-166.
- doi: 10.30773/pi.2018.12.11
OBJECTIVE: Some antidepressants have been implicated as risk factors for QT prolongation, which is a predictor of sudden cardiac death. However, the QT interval is considered an imperfect biomarker for... -
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- Visual Analysis of Regional Variations in Antidepressant Use and Suicide Rate
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Kim HJ, Lee IH
- KMID: 2437935
- Korean J Clin Pharm.
- 2018 Dec;28(4):308-319.
- doi: 10.24304/kjcp.2018.28.4.308
BACKGROUND: Some mental illnesses such as depression are known to be one of the risk factors of suicide and proper antidepressant therapy can reduce suicidal behavior. OBJECTIVES: This study aimed to... -
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