Psychiatry Investig.  2012 Jun;9(2):191-194.

No Association between PAWR Gene Polymorphisms and Tardive Dyskinesia in Schizophrenia Patients

• Kim IS
• Yoon HK
• Kang SG
• Park YM
• Kim YK
• Kim SH
• Choi JE
• Kim L
• Lee HJ

Abstract

Tardive dyskinesia (TD) is a hyperkinetic movement disorder associated with the prolonged use of antipsychotic drugs. Since prostate apoptosis response 4 (Par-4) is a key ligand of the dopamine D2 receptor, the Par-4 gene (PAWR) is a good candidate gene to study in the context of TD susceptibility. We examined the association between PAWR gene polymorphisms and TD. Three single nucleotide polymorphisms of PAWR were selected for the analysis: rs7979987, rs4842318, and rs17005769. Two hundred and eighty unrelated Korean schizophrenic patients participated in this study (105 TD and 175 non-TD patients). Genotype/allele-wise and haplotype-wise analyses were performed. There were no significant differences in genotype and allele frequencies between the two groups. Haplotype analysis also did not reveal a difference between the two groups. Within the limitations imposed by the size of the clinical sample, these findings suggest that PAWR gene variants do not significantly contribute to an increased risk of TD.

Keyword

Schizophrenia; Tardive dyskinesia; PAWR; Polymorphism

MeSH Terms

Antipsychotic Agents
Apoptosis
Gene Frequency
Genotype
Haplotypes
Humans
Hyperkinesis
Movement Disorders
Polymorphism, Single Nucleotide
Prostate
Receptors, Dopamine D2
Schizophrenia
Antipsychotic Agents
Receptors, Dopamine D2