Psychiatry Investig.  2009 Mar;6(1):34-38.

Nocturnal Sleep Related with Metabolic Markers in End-Stage Renal Disease Patients Receiving Hemodialysis

• Lee JH
• Kim SJ
• Jung HH

Abstract

OBJECTIVE
It has been suggested that oxidative stress and inflammation are associated with the pathophysiology of sleep disorders in end-stage renal disease (ESRD) patients. We examined the relationship of the sleep variables reflecting sleep breathing disorder and limb movements during sleep with the clinical variables reflecting the metabolic abnormalities in ESRD patients receiving hemodialysis. METHODS: Nocturnal polysomnography was conducted in 30 ESRD patients (21 men, 9 women), who were receiving hemodialysis. Blood was sampled before hemodialysis for each patient in order to measure uric acid (UA), C-reactive protein (CRP), and interleukin-6 (IL-6). RESULTS: UA was correlated positively with the total sleep time (TST)(r=0.407) and negatively with the apnea-hypopnea index (AHI) and oxygen desaturation index (ODI)(r=-0.377, -405). CONCLUSION: CRP was positively correlated with the limb movement index (LMI)(r=0.401). Our study showed that increased UA was related to decreased respiratory disturbance during sleep in ESRD patients receiving hemodialysis.

Keyword

End-stage renal disease; Nocturnal sleep; Uric acid; C-reactive protein; Sleep breathing disorder

MeSH Terms

C-Reactive Protein
Extremities
Humans
Inflammation
Interleukin-6
Kidney Failure, Chronic
Male
Oxidative Stress
Oxygen
Polysomnography
Renal Dialysis
Respiration
Sleep Wake Disorders
Uric Acid
C-Reactive Protein
Interleukin-6
Oxygen
Uric Acid