Pediatr Gastroenterol Hepatol Nutr.  2012 Mar;15(1):1-7.

Noroviruses: Recent Updates

• Chung JY

Abstract

Noroviruses (NoVs) are one major etiologic agent in acute gastroenteritis (AGE) in all ages and are the primary cause of food-borne gastroenteritis worldwide. GII-4 NoVs has predominated since 1990s, and novel recombinant strains have been reported worldwide. Researchers face difficulties in making vaccines and therapeutic agents against NoVs due to the lack of cell culture and animal-model systems and the rapid emergence of novel variant strains. Recently, a randomized clinical trial for intranasal NoVs vaccine has been reported, which casts a light in the way of vaccine production. This review discusses the recent findings on the structure, immunity, and vaccination of NoVs.

Keyword

Norovirus; Gastroenteritis; Children; Vaccine

MeSH Terms

Cell Culture Techniques
Child
Gastroenteritis
Humans
Light
Norovirus
Vaccination
Vaccines
Vaccines

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