Pediatr Allergy Respir Dis.  2012 Mar;22(1):116-121.

A Case Report of Food-Dependent Exercise-Induced Anaphylaxis in a Patient who was Sensitive to Pork

• Pang SJ
• No SJ
• Kim DW
• Lee SM
• Lee EJ
• Kim CH
• Lee HH
• Lee KE
• Hong JY
• Kim KE

Abstract

Food-dependent exercise-induced anaphylaxis (FDEIA) is a specific variant of exercise-induced anaphylaxis that requires both vigorous physical activity and the ingestion of specific foods. In particular, it is rare occurrence for FDEIA to be associated with meat in Korea. A 15-year-old female had generalized urticaria, dyspnea, severe cough, headache, dizziness, and vomiting after singing and dancing for 1 hour and after ingesting grilled pork. Skin prick tests showed a strong positive reaction to pork, whereas the results of an oral food challenge and exercise provocation tests were negative. However, the exercise provocation test after pork ingestion showed a positive reaction manifested by generalized urticaria, cough, mild dyspnea, and a 23% decreased peak expiratory flow rate. Three allergens to pork (67 kDa, 90 kDa, and 15 kDa) reacted with the patient's serum on immunoglobulin E immunoblotting. We report a case of pork-dependent exercise-induced anaphylaxis in a patient who was sensitive to pork.

Keyword

Food allergy; Sensitization to pork; Food-dependent exercise-induced anaphylaxis (FDEIA)

MeSH Terms

Adolescent
Allergens
Anaphylaxis
Cough
Dancing
Dizziness
Dyspnea
Eating
Female
Food Hypersensitivity
Headache
Humans
Immunoblotting
Immunoglobulin E
Immunoglobulins
Korea
Meat
Motor Activity
Peak Expiratory Flow Rate
Singing
Skin
Urticaria
Vomiting
Allergens
Immunoglobulin E
Immunoglobulins

Figure

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  Fig. 1 Plain chest X-ray shows hyperinflation in both lungs.

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  Fig. 2 Sodium dodecyl sulfate polyacrylamide gel electrophoresis analysis of pork treated with heating (10 %). M, molecular weight marker; Lane 1, raw boston butt; Lane 2, boiled boston butt; Lane 3, roasted boston butt; Lane 4, raw boned rib; Lane 5, boiled boned rib; Lane 6, roasted boned rib.

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  Fig. 3 Imunoglobulin E Immunoblotting of pork. M, molecular weight marker; Lane 1, raw boston butt; Lane 2, boiled boston butt; Lane 3, roasted boston butt; Lane 4, raw boned rib; Lane 5, boiled boned rib; Lane 6, roasted boned rib.

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