Pediatr Allergy Respir Dis.  2008 Jun;18(2):189-193.

Isolation of Enterovirus Type 71 in a 3-year-old Boy Suffering from Toxic Epidermal Necrolysis

• Han SM
• Han SH
• Song JW
• Lee YH
• Park KS
• Park JS

Abstract

Toxic epidermal necrolysis (TEN) is an exfoliative disease of skin and characterized by flaccid bullae and spreading erythema so that the skin has the appearance of being scalded. It results primarily from a toxic reaction to various drugs, but occasionally occurs as a result of infection, neoplastic conditions, or other exposure. Enterovirus 71 (EV 71), the most recently described serotype of the genus Enterovirus (family Picornaviridae), causes a variety of diseases, including aseptic meningitis, encephalitis, poliomyelitis-like paralysis, hand-foot-mouth disease, gastroenteritis, fever and rash. A 3-year-old boy presented at the Department of Pediatrics, Soonchunhyang University Cheonan Hospital due to TEN. There were no definite causes such as drug toxicity, Graft-Versus-Host disease (GVHD) and infection. However, we could have isolated EV 71 from the patient's stool. Until now, there have been no reports showing the relationship between EV 71 and TEN, we report here in a case of TEN-associated with EV 71. Further evaluation is needed to study the relationship of TEN with EV 71.

Keyword

Toxic epidermal necrolysis; Enterovirus 71; Child

MeSH Terms

Blister
Child
Drug Toxicity
Encephalitis
Enterovirus
Epidermal Necrolysis, Toxic
Erythema
Exanthema
Fever
Gastroenteritis
Graft vs Host Disease
Humans
Meningitis, Aseptic
Paralysis
Pediatrics
Preschool Child
Skin
Stress, Psychological