Pediatr Allergy Respir Dis.
2008 Jun;18(2):167-173.
The Relationship between BCG Vaccination and Allergic Diseases
- Affiliations
-
- 1Department of Pediatrics, University of Ulsan College of Medicine, Korea. sjhong@amc.seoul.kr
- 2Department of Pediatrics, College of Medicine, Inje University, Korea.
- 3Department of Pediatrics, College of Medicine, Hallym University, Korea.
- 4Department of Pediatrics, College of Medicine, Eulji University, Korea.
- 5Department of Pediatrics, College of Medicine, Yonsei University, Korea.
- 6Department of Pediatrics, College of Medicine, Inha University, Korea.
- 7Department of Pediatrics, College of Medicine, Sungkyunkwan University, Korea.
- 8Department of Pediatrics, College of Medicine, Ajou University, Suwon, Korea.
Abstract
- PURPOSE
An increase in the prevalence of allergic diseases in our country as well as countries with a western life style may be due to a decrease in exposure to infectious agents in the early life. The aim of this study is to identify the relationship between BCG vaccination and allergic diseases in school-aged children.
METHODS
A questionnaire survey was conducted on 8,378 elementary school children, in Seoul, Korea. Multiple logistic regression analysis was performed to investigate the independent relationship between BCG vaccination and allergic diseases.
RESULTS
The significant associations between BCG vaccination and diagnosis of asthma or current wheeze (adjusted OR: 0.49 [95% CI: 0.29-0.82], 0.51 [0.28-0.93], respectively), all being adjusted by confounding factors. However, there was no association between BCG vaccination and diagnosis of allergic rhinitis or atopic dermatitis, or current symptoms of allergic rhinitis or atopic dermatitis.
CONCLUSION
These findings suggest that BCG vaccination in early childhood may prevent the development of asthma in school-aged children in Seoul, Korea.
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